Detailed information of TA system TA221060

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 2853058..2853593
• Replicon: chromosome
• Accession: NZ_CP085688
• Organism: Providencia rettgeri strain 06-1619

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: LHK11_RS12905
• Protein ID: WP_140170723.1
• Coordinates: 2853285..2853593 (+)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: LHK11_RS12900
• Protein ID: WP_140170722.1
• Coordinates: 2853058..2853285 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LHK11_RS12880 (LHK11_12880)	2848340..2848780	+	441	WP_110591516.1	flagellar export chaperone FlgN	-
LHK11_RS12885 (LHK11_12885)	2848967..2849398	+	432	WP_140170720.1	hypothetical protein	-
LHK11_RS12890 (LHK11_12890)	2849551..2851650	-	2100	WP_004255687.1	flagellar biosynthesis protein FlhA	-
LHK11_RS12895 (LHK11_12895)	2851643..2852794	-	1152	WP_140170721.1	flagellar biosynthesis protein FlhB	-
LHK11_RS12900 (LHK11_12900)	2853058..2853285	+	228	WP_140170722.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
LHK11_RS12905 (LHK11_12905)	2853285..2853593	+	309	WP_140170723.1	CcdB family protein	Toxin
LHK11_RS12910 (LHK11_12910)	2853609..2854166	+	558	WP_140170724.1	hypothetical protein	-
LHK11_RS12915 (LHK11_12915)	2854209..2854415	-	207	WP_272661075.1	helix-turn-helix transcriptional regulator	-
LHK11_RS12920 (LHK11_12920)	2854613..2855251	-	639	WP_094961165.1	protein phosphatase CheZ	-
LHK11_RS12925 (LHK11_12925)	2855276..2855668	-	393	WP_004255705.1	chemotaxis response regulator CheY	-
LHK11_RS12930 (LHK11_12930)	2855710..2856777	-	1068	WP_140170725.1	chemotaxis response regulator protein-glutamate methylesterase	-
LHK11_RS12935 (LHK11_12935)	2856777..2857613	-	837	WP_004255713.1	chemotaxis protein-glutamate O-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-101)

Antitoxin

• Post-segregation antitoxin CcdA (5-75)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11770.87 Da
• Isoelectric Point: 8.0469

>T221060 WP_140170723.1 NZ_CP085688:2853285-2853593 [Providencia rettgeri]
MQYRLYQNRDDAIKYPYLLDIQSNIIDLLNTRLVIPLFDSRLVKKPLPARLNPQLVINGQVFILMTHQMACVPHSLLGKE
IVDLSSQRDTIKHAIDLLIDGF

Nucleotide

• Length: 309 bp

>T221060 NZ_CP117338:206799-207284 [Salmonella enterica subsp. enterica serovar Typhimurium]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8660.87 Da
• Isoelectric Point: 8.9375

>AT221060 WP_140170722.1 NZ_CP085688:2853058-2853285 [Providencia rettgeri]
MNRTKKTVSVTVAPELYEQARRAKLNLSAILACALQAELKRLEAQKWKNDNAEGFNELNRINEEYGLLSDKYKDF

Nucleotide

• Length: 228 bp

>AT221060 NZ_CP117338:206524-206811 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA