Detailed information of TA system TA022106

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 4819149..4819813
• Replicon: chromosome
• Accession: NC_009485
• Organism: Bradyrhizobium sp. BTAi1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A5EKD4
• Locus tag: BBTA_RS21525
• Protein ID: WP_012044619.1
• Coordinates: 4819406..4819813 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A5EKD3
• Locus tag: BBTA_RS21520
• Protein ID: WP_012044618.1
• Coordinates: 4819149..4819409 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BBTA_RS21490	4814161..4814589	-	429	WP_012044613.1	PaaI family thioesterase	-
BBTA_RS21495	4814674..4815495	+	822	WP_012044614.1	enoyl-CoA hydratase	-
BBTA_RS21500	4815733..4816317	+	585	WP_012044615.1	CoA-binding protein	-
BBTA_RS21505	4816545..4817828	+	1284	WP_012044616.1	O-acetylhomoserine aminocarboxypropyltransferase	-
BBTA_RS21510	4818146..4818340	-	195	WP_041750807.1	hypothetical protein	-
BBTA_RS21515	4818667..4819002	+	336	WP_012044617.1	hypothetical protein	-
BBTA_RS21520	4819149..4819409	+	261	WP_012044618.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
BBTA_RS21525	4819406..4819813	+	408	WP_012044619.1	type II toxin-antitoxin system VapC family toxin	Toxin
BBTA_RS21530	4820573..4821661	-	1089	WP_012044620.1	COX15/CtaA family protein	-
BBTA_RS21535	4821764..4821985	+	222	WP_012044621.1	DUF2842 domain-containing protein	-
BBTA_RS21540	4821986..4823047	-	1062	WP_012044622.1	polysaccharide deacetylase family protein	-
BBTA_RS21545	4823369..4824589	+	1221	WP_012044623.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-126)

Antitoxin

• SpoVT-AbrB domain (8-44)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14997.23 Da
• Isoelectric Point: 8.0445

>T22106 WP_012044619.1 NC_009485:4819406-4819813 [Bradyrhizobium sp. BTAi1]
MICLDTNIVIAAVSGRSTALRHRLGEQIRSGTPIGLSVVALFELRYGIARSTRRSENERLLDRFLSLGIELLPFDGSDAE
HAAEIRADLERKGTPIGAFDYLIAAQARRRDAALVTLNRREFERVPGLLVLDWPA

Nucleotide

• Length: 408 bp

>T22106 NC_009485:4819406-4819813 [Bradyrhizobium sp. BTAi1]
ATGATCTGTCTCGACACCAACATCGTCATTGCCGCGGTGAGCGGGCGCAGCACGGCTCTGCGGCATCGGCTCGGCGAACA
GATCCGCTCGGGCACTCCGATCGGGCTTTCCGTCGTCGCACTTTTCGAACTGCGCTATGGCATCGCGAGGAGCACCCGCC
GCTCGGAAAATGAACGCCTGCTCGACCGCTTTCTGAGTCTCGGCATCGAGCTGCTGCCCTTCGATGGGAGCGATGCCGAG
CATGCTGCCGAGATTCGGGCGGATCTCGAGAGAAAAGGGACGCCGATTGGCGCGTTCGACTATCTGATCGCGGCACAGGC
TCGCCGGCGTGACGCGGCACTGGTGACGTTGAACCGGCGTGAGTTCGAGCGTGTCCCTGGATTACTCGTGCTCGATTGGC
CGGCTTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9718.12 Da
• Isoelectric Point: 4.5141

>AT22106 WP_012044618.1 NC_009485:4819149-4819409 [Bradyrhizobium sp. BTAi1]
MTATAKLFMHGRSQAVRLPKEFRFEGTEVRVSKVGDKVILEPISKPPLDLDKFWDELDALGARDFLPEGLPDDPPLQPDP
RALFDE

Nucleotide

• Length: 261 bp

>AT22106 NC_009485:4819149-4819409 [Bradyrhizobium sp. BTAi1]
ATGACCGCGACCGCCAAGCTGTTCATGCACGGCCGCAGCCAAGCCGTACGCCTGCCAAAAGAGTTCCGTTTCGAAGGCAC
CGAGGTCCGCGTCAGCAAGGTCGGCGACAAGGTGATCCTGGAGCCGATATCCAAGCCGCCGCTCGATCTCGACAAGTTCT
GGGATGAGCTCGACGCCCTCGGCGCACGGGACTTTCTGCCCGAAGGGCTTCCGGACGACCCGCCGCTGCAGCCGGATCCG
CGCGCTCTGTTCGACGAATGA

Structures

Toxin

• AlphaFold DB: A5EKD4

Antitoxin

• AlphaFold DB: A5EKD3