Detailed information of TA system TA221059

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2329335..2330251
• Replicon: chromosome
• Accession: NZ_CP085688
• Organism: Providencia rettgeri strain 06-1619

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LHK11_RS10360
• Protein ID: WP_140172470.1
• Coordinates: 2329793..2330251 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LHK11_RS10355
• Protein ID: WP_140172471.1
• Coordinates: 2329335..2329796 (+)
• Length: 154 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LHK11_RS10325 (LHK11_10325)	2325002..2325616	+	615	WP_140172475.1	LysE family translocator	-
LHK11_RS10330 (LHK11_10330)	2325640..2326113	-	474	WP_096863737.1	NUDIX domain-containing protein	-
LHK11_RS10335 (LHK11_10335)	2326464..2327105	-	642	WP_140172473.1	leucine efflux protein LeuE	-
LHK11_RS10340 (LHK11_10340)	2327579..2328280	+	702	WP_140172472.1	AzlC family ABC transporter permease	-
LHK11_RS10345 (LHK11_10345)	2328277..2328591	+	315	WP_004254498.1	AzlD domain-containing protein	-
LHK11_RS10350 (LHK11_10350)	2328779..2329246	+	468	WP_036957750.1	DUF1456 family protein	-
LHK11_RS10355 (LHK11_10355)	2329335..2329796	+	462	WP_140172471.1	DUF2384 domain-containing protein	Antitoxin
LHK11_RS10360 (LHK11_10360)	2329793..2330251	+	459	WP_140172470.1	RES domain-containing protein	Toxin
LHK11_RS10365 (LHK11_10365)	2330252..2331142	-	891	WP_094960598.1	LysR family transcriptional regulator	-
LHK11_RS10370 (LHK11_10370)	2331188..2332147	-	960	WP_140172469.1	acetyl-CoA carboxylase carboxyl transferase subunit alpha	-
LHK11_RS10375 (LHK11_10375)	2332253..2332675	-	423	WP_094960600.1	helix-turn-helix domain-containing protein	-
LHK11_RS10380 (LHK11_10380)	2332706..2333233	-	528	WP_282555720.1	GNAT family N-acetyltransferase	-
LHK11_RS10385 (LHK11_10385)	2333250..2334716	-	1467	WP_140172467.1	AMP nucleosidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-145)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (38-95)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17159.73 Da
• Isoelectric Point: 6.4824

>T221059 WP_140172470.1 NZ_CP085688:2329793-2330251 [Providencia rettgeri]
MILYRLVKSNFAHDAWSGQGAMLYGGRWNHKGTPAVYTSTSISLATLEILVHINQDRLLSQFSLLSIDINDKYVMKLSLD
HLPTDWQQDPAPTSTMDIGTIWLNNQDSLALLIPSCIVPYEYNAIINPLHPQFQKVLHTVKPLDFSVDPRLA

Nucleotide

• Length: 459 bp

>T221059 NZ_CP117337:c135795-135445 [Salmonella enterica subsp. enterica serovar Dublin]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin

Protein

• Length: 154 a.a.
• Molecular weight: 17102.62 Da
• Isoelectric Point: 9.9140

>AT221059 WP_140172471.1 NZ_CP085688:2329335-2329796 [Providencia rettgeri]
MRNYIPITPLQPTASSFKPLWRHVGLPAERGIELTHFLRQGLSVSVLDNIQEWSGMSKTELLRISGINERNIARRKNAGQ
PLNADESERIARLVRVFDAAVRLFNGDKHAASDWLNHPVKGLGHLRPIELIATESGAIEVIDLIGRIEHGVFS

Nucleotide

• Length: 462 bp

>AT221059 NZ_CP117337:c135440-135138 [Salmonella enterica subsp. enterica serovar Dublin]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA