Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1690720..1691368 Replicon chromosome
Accession NZ_CP085688
Organism Providencia rettgeri strain 06-1619

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LHK11_RS07335 Protein ID WP_094961724.1
Coordinates 1691183..1691368 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LHK11_RS07330 Protein ID WP_094961723.1
Coordinates 1690720..1691133 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LHK11_RS07305 (LHK11_07305) 1686035..1687171 - 1137 WP_180359534.1 M4 family metallopeptidase -
LHK11_RS07310 (LHK11_07310) 1687330..1688247 - 918 WP_140172324.1 oxygen-dependent coproporphyrinogen oxidase -
LHK11_RS07315 (LHK11_07315) 1688384..1688815 + 432 WP_109911483.1 GNAT family acetyltransferase -
LHK11_RS07320 (LHK11_07320) 1688907..1689512 + 606 WP_140172325.1 RpoE-regulated lipoprotein -
LHK11_RS07325 (LHK11_07325) 1689755..1690654 + 900 WP_094961722.1 Dyp-type peroxidase -
LHK11_RS07330 (LHK11_07330) 1690720..1691133 - 414 WP_094961723.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LHK11_RS07335 (LHK11_07335) 1691183..1691368 - 186 WP_094961724.1 type II toxin-antitoxin system HicA family toxin Toxin
LHK11_RS07340 (LHK11_07340) 1691691..1692713 + 1023 WP_140172326.1 sulfate ABC transporter substrate-binding protein -
LHK11_RS07345 (LHK11_07345) 1692713..1693543 + 831 WP_004264883.1 sulfate/thiosulfate ABC transporter permease CysT -
LHK11_RS07350 (LHK11_07350) 1693543..1694403 + 861 WP_200129238.1 sulfate/thiosulfate ABC transporter permease CysW -
LHK11_RS07355 (LHK11_07355) 1694406..1695494 + 1089 WP_094961726.1 sulfate/thiosulfate ABC transporter ATP-binding protein CysA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6992.20 Da        Isoelectric Point: 11.0146

>T221058 WP_094961724.1 NZ_CP085688:c1691368-1691183 [Providencia rettgeri]
VQSSELINILQKNGWKLERIKGSHHQFSHPHFSIVITVPHPQKDLKIGTLNHILKAAKLKH

Download         Length: 186 bp

>T221058 NZ_CP117337:47966-48271 [Salmonella enterica subsp. enterica serovar Dublin]
ATGCAGTTTAAGGTTTACACCTGTAAAAGGGAGAGTCGCTACCGGCTGTTTGTGGACGTGCAGAGCGACATCATTGACAC
CCCCGGACGGCGGATGGCTGTCCCGCTGGTCAGCGCCCGTCTGCTGTCGGAAAAGGTTCCCCGCGATCTTTACCCGGTGA
TGCATATCGGGGATGAGCCTTACCGCCTGCTGACCACGGATATGACCAGTGTGCCGGCCACCGTCATCGGGGAAGAGGTG
GCCGATCTCAGCCTCCGGGAGAACGATATCAAAAACGCCATTAACCTGATGTTCCGGGGGATCTGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15362.31 Da        Isoelectric Point: 4.6719

>AT221058 WP_094961723.1 NZ_CP085688:c1691133-1690720 [Providencia rettgeri]
MLYTAFIEIDNDGSASGWFPDIEGCTFAGSNIEEAYAEAKSAIDAHFELLSEKGFEIPLSKSQQTLLNPIQPEYAHGIWL
FVDVDMDKYDGRTERINITLPHRLLHRIDALVKVNPEYGSRSGFIAAAARKELKKTD

Download         Length: 414 bp

>AT221058 NZ_CP117337:47746-47964 [Salmonella enterica subsp. enterica serovar Dublin]
ATGAAGCAGCGAATTACAGTGACAGTGGACAGCGACAGCTATCAGCTGCTCAAGGCATACGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGAGCCGAACGCTGGCAGGAAGAAAATCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATAGAGGCTAACGGATCGTTTGCTGACGACAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References