Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 864348..864994 Replicon chromosome
Accession NZ_CP085688
Organism Providencia rettgeri strain 06-1619

Toxin (Protein)


Gene name Hha Uniprot ID B6XA97
Locus tag LHK11_RS03710 Protein ID WP_004905417.1
Coordinates 864348..864551 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID D4C184
Locus tag LHK11_RS03715 Protein ID WP_004905413.1
Coordinates 864626..864994 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LHK11_RS03685 (LHK11_03685) 860423..860761 + 339 WP_004905421.1 P-II family nitrogen regulator -
LHK11_RS03690 (LHK11_03690) 860811..862058 + 1248 WP_227528974.1 ammonium transporter AmtB -
LHK11_RS03695 (LHK11_03695) 862197..863066 - 870 WP_109911901.1 acyl-CoA thioesterase II -
LHK11_RS03700 (LHK11_03700) 863306..863764 + 459 WP_140172116.1 YbaY family lipoprotein -
LHK11_RS03710 (LHK11_03710) 864348..864551 - 204 WP_004905417.1 HHA domain-containing protein Toxin
LHK11_RS03715 (LHK11_03715) 864626..864994 - 369 WP_004905413.1 Hha toxicity modulator TomB Antitoxin
LHK11_RS03720 (LHK11_03720) 865518..866888 - 1371 WP_136135575.1 murein transglycosylase D -
LHK11_RS03725 (LHK11_03725) 866970..867725 - 756 WP_140172117.1 hydroxyacylglutathione hydrolase -
LHK11_RS03730 (LHK11_03730) 867798..868499 + 702 WP_227528900.1 methyltransferase domain-containing protein -
LHK11_RS03735 (LHK11_03735) 868496..868966 - 471 WP_004905405.1 ribonuclease HI -
LHK11_RS03740 (LHK11_03740) 869021..869782 + 762 WP_140172118.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8061.34 Da        Isoelectric Point: 6.9770

>T221055 WP_004905417.1 NZ_CP085688:c864551-864348 [Providencia rettgeri]
MTKSDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T221055 NZ_CP117336:4654499-4654810 [Salmonella enterica subsp. enterica serovar Dublin]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGATCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14085.04 Da        Isoelectric Point: 4.4915

>AT221055 WP_004905413.1 NZ_CP085688:c864994-864626 [Providencia rettgeri]
MDEYSPKRHDIAELKYLCNSLNRDAILSLQKTNTHWINDLSSPQSAALNELIEHIAAFVWRFKIKYPKENLVISLIEEYL
DETYDLFGSPVITLSEIIDWEAMNHSLVAVLDDDLKCLTSKT

Download         Length: 369 bp

>AT221055 NZ_CP117336:4654807-4655253 [Salmonella enterica subsp. enterica serovar Dublin]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAATCACTCAAC
CAACACCTGGAGAAAACACCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATCAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A291E6Q2

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6Q6D9

References