Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 1478275..1478913 Replicon chromosome
Accession NZ_CP085682
Organism Paenibacillus polymyxa strain YS18-2

Toxin (Protein)


Gene name pemK Uniprot ID H6CFY1
Locus tag LJR53_RS06195 Protein ID WP_007429335.1
Coordinates 1478563..1478913 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID H6CFY0
Locus tag LJR53_RS06190 Protein ID WP_007429334.1
Coordinates 1478275..1478556 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJR53_RS06170 1473291..1474262 - 972 WP_102998547.1 ABC transporter substrate-binding protein -
LJR53_RS06175 1474497..1475129 + 633 WP_045244041.1 LysE family transporter -
LJR53_RS06180 1475240..1476517 + 1278 WP_017426524.1 outer membrane lipoprotein-sorting protein -
LJR53_RS06185 1476785..1477981 + 1197 WP_102998775.1 alanine racemase -
LJR53_RS06190 1478275..1478556 + 282 WP_007429334.1 ribbon-helix-helix protein, CopG family Antitoxin
LJR53_RS06195 1478563..1478913 + 351 WP_007429335.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LJR53_RS06200 1479092..1481314 + 2223 WP_025364306.1 Tex family protein -
LJR53_RS06205 1481418..1481552 - 135 WP_016821163.1 cortex morphogenetic protein CmpA -
LJR53_RS06210 1481695..1482207 + 513 WP_016821162.1 SprT family protein -
LJR53_RS06225 1482586..1483461 - 876 WP_257126791.1 Cof-type HAD-IIB family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12822.77 Da        Isoelectric Point: 5.6195

>T221047 WP_007429335.1 NZ_CP085682:1478563-1478913 [Paenibacillus polymyxa]
MIVKRGDVFFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAATHGFDRDSVVLLEQI
RTIDKQRLTDKITHLDEETMRKVSDSLQISLGLIDF

Download         Length: 351 bp

>T221047 NZ_CP117336:c2725893-2725790 [Salmonella enterica subsp. enterica serovar Dublin]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10636.25 Da        Isoelectric Point: 8.5257

>AT221047 WP_007429334.1 NZ_CP085682:1478275-1478556 [Paenibacillus polymyxa]
MANLQNTKRIMISLPDHLLQEVDGIVAMENSNRSEFIRQAMKLYVGERKKRYIREAMQRGYMEMAKINLTMASEAFHAEE
DANSTLGRTVSGV

Download         Length: 282 bp

>AT221047 NZ_CP117336:2725788-2725933 [Salmonella enterica subsp. enterica serovar Dublin]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H6CFY1

Antitoxin

Source ID Structure
AlphaFold DB H6CFY0

References