Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3716235..3716889 Replicon chromosome
Accession NZ_CP085638
Organism Escherichia coli strain fEC.1

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag LJX82_RS17870 Protein ID WP_063112724.1
Coordinates 3716235..3716642 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag LJX82_RS17875 Protein ID WP_000354046.1
Coordinates 3716623..3716889 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJX82_RS17850 (3712192) 3712192..3713925 - 1734 WP_000813210.1 single-stranded-DNA-specific exonuclease RecJ -
LJX82_RS17855 (3713931) 3713931..3714641 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LJX82_RS17860 (3714666) 3714666..3715562 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
LJX82_RS17865 (3715674) 3715674..3716195 + 522 WP_001055874.1 flavodoxin FldB -
LJX82_RS17870 (3716235) 3716235..3716642 - 408 WP_063112724.1 protein YgfX Toxin
LJX82_RS17875 (3716623) 3716623..3716889 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
LJX82_RS17880 (3717132) 3717132..3718112 + 981 WP_001472148.1 tRNA-modifying protein YgfZ -
LJX82_RS17885 (3718189) 3718189..3718848 - 660 WP_000250274.1 hemolysin III family protein -
LJX82_RS17890 (3719012) 3719012..3719323 - 312 WP_001182944.1 N(4)-acetylcytidine aminohydrolase -
LJX82_RS17895 (3719368) 3719368..3720801 + 1434 WP_227536568.1 6-phospho-beta-glucosidase BglA -
LJX82_RS17900 (3720858) 3720858..3721601 - 744 WP_000951964.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16082.04 Da        Isoelectric Point: 11.2511

>T221043 WP_063112724.1 NZ_CP085638:c3716642-3716235 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLFHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T221043 NZ_CP117336:358260-358535 [Salmonella enterica subsp. enterica serovar Dublin]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT221043 WP_000354046.1 NZ_CP085638:c3716889-3716623 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT221043 NZ_CP117336:357997-358257 [Salmonella enterica subsp. enterica serovar Dublin]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCACGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References