Detailed information of TA system TA221031

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2158165..2159261
• Replicon: chromosome
• Accession: NZ_CP085638
• Organism: Escherichia coli strain fEC.1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A8S7TJ53
• Locus tag: LJX82_RS10465
• Protein ID: WP_063112742.1
• Coordinates: 2158431..2159261 (+)
• Length: 277 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LJX82_RS10460
• Protein ID: WP_001296726.1
• Coordinates: 2158165..2158431 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJX82_RS10455 (2154459)	2154459..2157956	+	3498	Protein_2035	ECSE_1600 family autotransporter	-
LJX82_RS10460 (2158165)	2158165..2158431	+	267	WP_001296726.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
LJX82_RS10465 (2158431)	2158431..2159261	+	831	WP_063112742.1	HipA N-terminal domain-containing protein	Toxin
LJX82_RS10470 (2159573)	2159573..2159781	+	209	Protein_2038	AraC family transcriptional regulator	-
LJX82_RS10475 (2160213)	2160213..2160776	+	564	WP_001296758.1	type 1 fimbrial major subunit FimA	-
LJX82_RS10480 (2161136)	2161136..2161846	+	711	WP_001195166.1	fimbria/pilus periplasmic chaperone	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimA	2153141..2175098	21957
	-	flank	IS/Tn	-	-	2153141..2154349	1208

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (115-237)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 277 a.a.
• Molecular weight: 31181.99 Da
• Isoelectric Point: 10.0235

>T221031 WP_063112742.1 NZ_CP085638:2158431-2159261 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEDRYDFMKFQVFQWLIGATDGHAKNFSVFIQAGGS
YRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIPAALD
NVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Nucleotide

• Length: 831 bp

>T221031 NZ_CP117332:2366147-2366431 [Salmonella enterica subsp. enterica serovar Muenster]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAGTGACACAACACAGAAGCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10047.39 Da
• Isoelectric Point: 4.9632

>AT221031 WP_001296726.1 NZ_CP085638:2158165-2158431 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT221031 NZ_CP117332:2365909-2366157 [Salmonella enterica subsp. enterica serovar Muenster]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA