Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapB(antitoxin)
Location 4515374..4515929 Replicon chromosome
Accession NC_009483
Organism Geobacter uraniireducens Rf4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GURA_RS23755 Protein ID WP_011940659.1
Coordinates 4515374..4515730 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GURA_RS19675 Protein ID WP_041245571.1
Coordinates 4515732..4515929 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GURA_RS19650 4511246..4512865 - 1620 WP_011940656.1 phosphoglycerate dehydrogenase -
GURA_RS19655 4512934..4514214 - 1281 WP_011940657.1 MFS transporter -
GURA_RS19665 4514956..4515234 + 279 WP_157046254.1 hypothetical protein -
GURA_RS23755 4515374..4515730 - 357 WP_011940659.1 type II toxin-antitoxin system VapC family toxin Toxin
GURA_RS19675 4515732..4515929 - 198 WP_041245571.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
GURA_RS19680 4516205..4516585 - 381 WP_011940661.1 type II toxin-antitoxin system VapC family toxin -
GURA_RS19685 4516586..4516819 - 234 WP_011940662.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
GURA_RS19690 4517119..4517547 + 429 WP_011940663.1 putative toxin-antitoxin system toxin component, PIN family -
GURA_RS19695 4517544..4517780 + 237 WP_011940664.1 toxin-antitoxin system HicB family antitoxin -
GURA_RS19700 4517809..4518403 - 595 Protein_3962 ABC transporter permease -
GURA_RS24460 4518408..4518569 - 162 WP_011940665.1 hypothetical protein -
GURA_RS19705 4518627..4518989 - 363 WP_011940666.1 hypothetical protein -
GURA_RS19710 4518986..4520743 - 1758 WP_011940667.1 ABC transporter ATP-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-110)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13080.29 Da        Isoelectric Point: 4.8122

>T22102 WP_011940659.1 NC_009483:c4515730-4515374 [Geobacter uraniireducens Rf4]
MILVDTSVWVEHLRSGTIGLDALLTDGQVVIHPFVIGELACGNLKNRTEILSLLQDLPMASCADDDEVIEFINDHKLMGK
GLGYIDIHLLMSALLTRIPLWTIDKRLHEASLSLLPTH

Download         Length: 357 bp

>T22102 NC_009483:c4515730-4515374 [Geobacter uraniireducens Rf4]
ATGATTCTTGTTGATACGTCGGTCTGGGTAGAACATTTACGATCCGGAACTATCGGACTTGATGCACTCTTAACTGATGG
CCAGGTAGTTATTCACCCATTTGTTATTGGTGAACTGGCATGCGGAAACCTCAAAAATAGAACAGAAATACTCTCTCTTC
TTCAGGACCTTCCTATGGCATCCTGCGCAGATGATGATGAGGTAATTGAATTCATTAACGATCACAAGCTTATGGGTAAA
GGGCTCGGTTATATCGACATTCATTTGCTTATGTCTGCCCTGCTGACCAGAATACCCCTATGGACAATTGATAAACGGTT
GCATGAGGCTTCGCTGTCACTACTGCCGACACATTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7105.42 Da        Isoelectric Point: 11.1264

>AT22102 WP_041245571.1 NC_009483:c4515929-4515732 [Geobacter uraniireducens Rf4]
MRTTLNIEDALLEKAAKLTGITEKTSLVRLGLQALIAKESSKRLAGLGGTEKNLKMIPRRRTEGI

Download         Length: 198 bp

>AT22102 NC_009483:c4515929-4515732 [Geobacter uraniireducens Rf4]
ATGAGAACTACGCTTAATATCGAAGATGCTCTGTTGGAAAAAGCTGCGAAATTGACTGGCATAACGGAAAAAACATCCCT
TGTCAGGCTTGGGTTACAAGCACTTATTGCCAAGGAAAGCTCGAAGCGACTTGCCGGATTGGGTGGGACTGAAAAGAATT
TGAAAATGATTCCTCGAAGAAGAACAGAGGGTATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References