Detailed information of TA system TA221015

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2329844..2331432
• Replicon: chromosome
• Accession: NZ_CP085637
• Organism: Escherichia coli strain fECg99.1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: F4NFZ0
• Locus tag: LJU33_RS11255
• Protein ID: WP_001125463.1
• Coordinates: 2330110..2331432 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LJU33_RS11250
• Protein ID: WP_001296726.1
• Coordinates: 2329844..2330110 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJU33_RS11250 (2329844)	2329844..2330110	+	267	WP_001296726.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
LJU33_RS11255 (2330110)	2330110..2331432	+	1323	WP_001125463.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
LJU33_RS11260 (2331744)	2331744..2331952	+	209	Protein_2198	AraC family transcriptional regulator	-
LJU33_RS11265 (2332386)	2332386..2332949	+	564	WP_023156469.1	type 1 fimbrial major subunit FimA	-
LJU33_RS11270 (2333310)	2333310..2334020	+	711	WP_001195172.1	fimbria/pilus periplasmic chaperone	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimA	2329844..2345933	16089

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (7-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49422.05 Da
• Isoelectric Point: 9.1203

>T221015 WP_001125463.1 NZ_CP085637:2330110-2331432 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALRDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Nucleotide

• Length: 1323 bp

>T221015 NZ_CP117329:c1921843-1921511 [Salmonella enterica subsp. enterica serovar Muenster]
ATGGACAGAGGGGAAATCTGGCTCGTTTCACTGGATCCGATTGCCGGCCATGAGCAAAGTGGAAAACGTCCGGTACTCAT
CGTATCGCAAGCATCGTTTAACAAGCTGACCCGACTACCCGTTGTTGTTCCCGTCACCAGCGGCGGAAACTTTGCCCGTG
CAGCCGGTTTTACCGTCTCACTGGACGACGCGGGAACGAAAACAACGGGCGTAATCCGCTGCGACCAGCCCAGAACCATT
GATATGGGAGCCCGAAATGGCAAGCGACTGGAGCGCATACCCGACGCTGTCGTGAATGAAGTGCTGGCCCGACTGGAAGC
CATTTTGAGTTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10047.39 Da
• Isoelectric Point: 4.9632

>AT221015 WP_001296726.1 NZ_CP085637:2329844-2330110 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT221015 NZ_CP117329:c1922101-1921844 [Salmonella enterica subsp. enterica serovar Muenster]
ATGTATACAACTCGCCTGAAAAAGGTCGGCGGATCCGTCATGCTGGCGGTTCCTCCCGCCGTGTTGAAAACGCTGGCGCT
GTCGACAGATAGCGAAGTGGGAATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAGACGGCCCCGTTATTCGC
TTGAGGAACTGCTGGCGCAGTGCGATCCGCACGCAGAAATGAGTGAGGAAGATCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGCTCCTGTAA

Structures

Toxin

• AlphaFold DB: A0A7U9IYX0