Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 273548..274179 Replicon chromosome
Accession NZ_CP085637
Organism Escherichia coli strain fECg99.1

Toxin (Protein)


Gene name hicA Uniprot ID F4NNK6
Locus tag LJU33_RS01255 Protein ID WP_001259388.1
Coordinates 273548..273823 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A8S7TCM0
Locus tag LJU33_RS01260 Protein ID WP_000593556.1
Coordinates 273820..274179 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJU33_RS01240 (268552) 268552..269619 + 1068 WP_000361485.1 HlyD family secretion protein -
LJU33_RS01245 (269616) 269616..272351 + 2736 WP_000149125.1 ribosome-associated ATPase/putative transporter RbbA -
LJU33_RS01250 (272351) 272351..273475 + 1125 WP_001314210.1 ABC transporter permease -
LJU33_RS01255 (273548) 273548..273823 + 276 WP_001259388.1 type II toxin-antitoxin system HicA family toxin Toxin
LJU33_RS01260 (273820) 273820..274179 + 360 WP_000593556.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LJU33_RS01265 (274299) 274299..274700 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
LJU33_RS01270 (274706) 274706..275512 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
LJU33_RS01275 (275509) 275509..276273 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
LJU33_RS01280 (276273) 276273..277106 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
LJU33_RS01285 (277103) 277103..278047 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10151.89 Da        Isoelectric Point: 10.7076

>T221001 WP_001259388.1 NZ_CP085637:273548-273823 [Escherichia coli]
MRTKVQALRKKQKNTLDQIVKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T221001 NZ_CP117327:1988971-1989074 [Salmonella enterica subsp. enterica serovar Saintpaul]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13388.25 Da        Isoelectric Point: 5.1987

>AT221001 WP_000593556.1 NZ_CP085637:273820-274179 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHV

Download         Length: 360 bp

>AT221001 NZ_CP117327:c1989076-1988931 [Salmonella enterica subsp. enterica serovar Saintpaul]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A0FFA2

Antitoxin

Source ID Structure

References