Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 5572411..5573952 Replicon chromosome
Accession NZ_CP085636
Organism Shewanella sp. MTB7

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HWQ47_RS24315 Protein ID WP_269968553.1
Coordinates 5572411..5573712 (-) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HWQ47_RS24320 Protein ID WP_269968554.1
Coordinates 5573716..5573952 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWQ47_RS24295 (HWQ47_24330) 5568051..5568722 + 672 WP_269971850.1 DUF2461 domain-containing protein -
HWQ47_RS24300 (HWQ47_24335) 5568739..5569932 - 1194 WP_269968550.1 ISL3 family transposase -
HWQ47_RS24305 (HWQ47_24340) 5570252..5570731 + 480 WP_269968551.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
HWQ47_RS24310 (HWQ47_24345) 5570827..5572128 - 1302 WP_269968552.1 hemolysin family protein -
HWQ47_RS24315 (HWQ47_24350) 5572411..5573712 - 1302 WP_269968553.1 HipA domain-containing protein Toxin
HWQ47_RS24320 (HWQ47_24355) 5573716..5573952 - 237 WP_269968554.1 helix-turn-helix domain-containing protein Antitoxin
HWQ47_RS24325 (HWQ47_24360) 5574233..5574415 - 183 WP_269968555.1 hypothetical protein -
HWQ47_RS24330 (HWQ47_24365) 5574661..5575671 + 1011 WP_269968556.1 nuclease-related domain-containing protein -
HWQ47_RS24335 (HWQ47_24370) 5575944..5576270 + 327 WP_269968557.1 hypothetical protein -
HWQ47_RS24340 (HWQ47_24375) 5576456..5576644 + 189 Protein_4734 nuclease -
HWQ47_RS24345 (HWQ47_24380) 5576920..5577054 + 135 Protein_4735 nuclease -
HWQ47_RS24350 (HWQ47_24385) 5577078..5577989 + 912 WP_269968558.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 5568739..5569638 899


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-64)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48611.60 Da        Isoelectric Point: 4.8435

>T220999 WP_269968553.1 NZ_CP085636:c5573712-5572411 [Shewanella sp. MTB7]
MADSVNLVLDMHLGEQIIGELSFDTATETFAVNYTNDWQQRGFPISPMIPLDGSGRSNQISMFLVNLLPENKGLDYLIES
LGVSRGNTFALVRGIGLDTAGAIAFSLKESLLPETSFRAISDAEVIKRLEDPDSWPMEVWDGKPRLSVAGVQSKLNLFYN
GKAFGFAEGALSSTHILKFEKHQHLVINEFLTMRLAKAISMHVANVEISYFGQYKALCVERFDRRYLPDEHKVLRRHIID
SCQTLGFSVNKKYERNFGAGHDVRDIREGVSFARLFGLASQCSNPAAAKQDMLQWALFNLLSGNADAHGKNYSFFMTPEG
LVPTPWYDLVCVTLYDEFEQEMAMAIDDEFDPNKIYAYQLASFIEDIGLPRTLLINNLTQMATKITQVIDNVIVMLPALD
KAEQDFVDAYKALLLARCERYLASAAEIKNIEL

Download         Length: 1302 bp

>T220999 NZ_CP117327:848084-848482 [Salmonella enterica subsp. enterica serovar Saintpaul]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCAAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTAGTGGAGGGATTTATCTCCCGCCTTGAGGTTTTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATAGAAGACTGGTGCTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8430.83 Da        Isoelectric Point: 10.0139

>AT220999 WP_269968554.1 NZ_CP085636:c5573952-5573716 [Shewanella sp. MTB7]
MGPTLNQQSLGLLVKENRKKAGLTQEVAAMLCGVTKKTFIRVEKGEDVYISTVFKILDGLGVAIVAKQNSTTNASGWY

Download         Length: 237 bp

>AT220999 NZ_CP117327:847857-848084 [Salmonella enterica subsp. enterica serovar Saintpaul]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References