Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4235135..4235767 Replicon chromosome
Accession NZ_CP085636
Organism Shewanella sp. MTB7

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HWQ47_RS18395 Protein ID WP_269967515.1
Coordinates 4235369..4235767 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HWQ47_RS18390 Protein ID WP_269967514.1
Coordinates 4235135..4235368 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWQ47_RS18370 (HWQ47_18390) 4230716..4231333 + 618 WP_269967510.1 NAD(P)H-dependent oxidoreductase -
HWQ47_RS18375 (HWQ47_18395) 4231359..4233284 + 1926 WP_269967511.1 monovalent cation:proton antiporter-2 (CPA2) family protein -
HWQ47_RS18380 (HWQ47_18400) 4233294..4234712 - 1419 WP_269967512.1 leucine-rich repeat-containing protein kinase family protein -
HWQ47_RS18385 (HWQ47_18405) 4234902..4235063 - 162 WP_269967513.1 hypothetical protein -
HWQ47_RS18390 (HWQ47_18410) 4235135..4235368 + 234 WP_269967514.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HWQ47_RS18395 (HWQ47_18415) 4235369..4235767 + 399 WP_269967515.1 tRNA(fMet)-specific endonuclease VapC Toxin
HWQ47_RS18400 (HWQ47_18420) 4235840..4236778 - 939 WP_269967516.1 M14 family metallocarboxypeptidase -
HWQ47_RS18405 (HWQ47_18425) 4236875..4237294 - 420 WP_269967517.1 hypothetical protein -
HWQ47_RS18410 (HWQ47_18430) 4237315..4237698 - 384 WP_269967518.1 hypothetical protein -
HWQ47_RS18415 (HWQ47_18435) 4238163..4239029 + 867 WP_269967519.1 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14763.09 Da        Isoelectric Point: 7.9435

>T220998 WP_269967515.1 NZ_CP085636:4235369-4235767 [Shewanella sp. MTB7]
MLKYMLDTNICIYVIKKKPLEALQAFNLHAGQLCISSITLAELLHGASKSVKPEHNLRIVEDFVSRLDVLNYGAKAASHY
GDIRANLERKGTPIGVNDLHISGHARSEALIIVTNNEKEFIRVDGLRVENWV

Download         Length: 399 bp

>T220998 NZ_CP117327:837216-837629 [Salmonella enterica subsp. enterica serovar Saintpaul]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8833.91 Da        Isoelectric Point: 4.7247

>AT220998 WP_269967514.1 NZ_CP085636:4235135-4235368 [Shewanella sp. MTB7]
MSVASVFINNRTQAVRLPVDSRFPEDVKKVNVRVVGKERILSPIDNTWDSFFLPQTSVTDDFMAERASQEQAERESF

Download         Length: 234 bp

>AT220998 NZ_CP117327:836969-837235 [Salmonella enterica subsp. enterica serovar Saintpaul]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References