Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 444088..445691 Replicon chromosome
Accession NZ_CP085636
Organism Shewanella sp. MTB7

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HWQ47_RS01990 Protein ID WP_269969534.1
Coordinates 444369..445691 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HWQ47_RS01985 Protein ID WP_269969533.1
Coordinates 444088..444369 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWQ47_RS01965 (HWQ47_01975) 439160..439543 - 384 WP_269969529.1 hypothetical protein -
HWQ47_RS01970 (HWQ47_01980) 439550..441925 - 2376 WP_269969530.1 hypothetical protein -
HWQ47_RS01975 (HWQ47_01985) 442316..442618 - 303 WP_269969531.1 helix-hairpin-helix domain-containing protein -
HWQ47_RS01980 (HWQ47_01990) 443065..443790 + 726 WP_269969532.1 amino acid adenylation -
HWQ47_RS01985 (HWQ47_01995) 444088..444369 + 282 WP_269969533.1 helix-turn-helix domain-containing protein Antitoxin
HWQ47_RS01990 (HWQ47_02000) 444369..445691 + 1323 WP_269969534.1 type II toxin-antitoxin system HipA family toxin Toxin
HWQ47_RS01995 (HWQ47_02005) 446097..446957 - 861 WP_269969535.1 hypothetical protein -
HWQ47_RS02000 447230..447364 - 135 WP_269969536.1 hypothetical protein -
HWQ47_RS02005 (HWQ47_02010) 447375..447515 - 141 WP_269969537.1 hypothetical protein -
HWQ47_RS02010 (HWQ47_02015) 447574..447777 - 204 WP_269969538.1 hypothetical protein -
HWQ47_RS02015 (HWQ47_02020) 447837..448733 - 897 WP_269969539.1 viperin family antiviral radical SAM protein -
HWQ47_RS02020 (HWQ47_02025) 448808..449473 - 666 WP_269969540.1 hypothetical protein -
HWQ47_RS02025 (HWQ47_02030) 449466..449846 - 381 WP_269969541.1 hypothetical protein -
HWQ47_RS02030 (HWQ47_02035) 449846..450463 - 618 WP_269969542.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49385.03 Da        Isoelectric Point: 6.7256

>T220996 WP_269969534.1 NZ_CP085636:444369-445691 [Shewanella sp. MTB7]
MAVLDVYVNGYLVGEFTKSTTGSHLFKYAPKWLTTPGSRPISLSMPLRSQAYKGDEVYNFFDNLLPDNMEVRNRIVARHN
AQSTQAFDLLAKVGQDSVGALQLVLHGQHPFDVKKIEAKDLSDEALEKVLKGYQSDIPLGMLVDEDDFRISIAGAQEKTA
LLNLDGRWQLPIKATPTTHIIKLPIGEIQSHSYTIDMNDSVENEYLCMMIVREFGLDVPHCSILKVGDIKALAVARFDRK
LSSDGQWIMRLPQEDFCQTLNIPPAKKYESHGGPGIEQIMLYLLGSMNSERDRYNLMKSQVLFWLLAATDGHAKNFSLFI
EVGGGYRLTPFYDIISMYPVIGGKGLNIRDAKLAMGLKATKGKKYQIAQIFPRHFLQTAKAVGFDLDAMVDILREVADSV
DDVIMRVKAQLPEDFPVHIRDSILDGLKDRAKRLIAESYI

Download         Length: 1323 bp

>T220996 NZ_CP117327:316616-316984 [Salmonella enterica subsp. enterica serovar Saintpaul]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTATCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTTGCTATATCCCGTGGGTATATCTTCAATGATGGTAACAAACGCACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10604.94 Da        Isoelectric Point: 5.1851

>AT220996 WP_269969533.1 NZ_CP085636:444088-444369 [Shewanella sp. MTB7]
MKVTNSKQLSAYLKDARLNMKLSQSKVGSKVGIRQDTVSSFEQNPDSTKLETLFKILSALNLELDIKVRNSELTEQLNDD
KSAASEQEWKEEW

Download         Length: 282 bp

>AT220996 NZ_CP117327:316398-316619 [Salmonella enterica subsp. enterica serovar Saintpaul]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGAAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References