220993

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3836725..3837365 Replicon chromosome
Accession NZ_CP085633
Organism Pectobacterium brasiliense strain TS20HJ1

Toxin (Protein)


Gene name vagD Uniprot ID A0A7V8Q162
Locus tag LJQ72_RS17295 Protein ID WP_039278477.1
Coordinates 3836725..3837141 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A086EF97
Locus tag LJQ72_RS17300 Protein ID WP_039278475.1
Coordinates 3837138..3837365 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJQ72_RS17275 (LJQ72_17275) 3832309..3833295 - 987 WP_040033638.1 quinone oxidoreductase -
LJQ72_RS17280 (LJQ72_17280) 3833424..3834830 + 1407 WP_010279223.1 replicative DNA helicase -
LJQ72_RS17285 (LJQ72_17285) 3834872..3835954 + 1083 WP_104209466.1 alanine racemase -
LJQ72_RS17290 (LJQ72_17290) 3835947..3836585 + 639 WP_039517591.1 hypothetical protein -
LJQ72_RS17295 (LJQ72_17295) 3836725..3837141 - 417 WP_039278477.1 type II toxin-antitoxin system VapC family toxin Toxin
LJQ72_RS17300 (LJQ72_17300) 3837138..3837365 - 228 WP_039278475.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LJQ72_RS17305 (LJQ72_17305) 3839059..3839538 + 480 WP_010295086.1 Lrp/AsnC family transcriptional regulator -
LJQ72_RS17310 (LJQ72_17310) 3839789..3840403 + 615 WP_014916569.1 YitT family protein -
LJQ72_RS17315 (LJQ72_17315) 3840467..3841660 + 1194 WP_039465897.1 amino acid aminotransferase -
LJQ72_RS17320 (LJQ72_17320) 3841744..3842241 + 498 WP_039278469.1 M48 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15274.80 Da        Isoelectric Point: 8.2931

>T220993 WP_039278477.1 NZ_CP085633:c3837141-3836725 [Pectobacterium brasiliense]
VSRLFMLDTNICSFIMREHPAEVIEKLQQCTLRRDRIVVSAITYAEMRFGAVGKKASPRHMQLVDAFCRRLDAVLPWDSA
AVDATTKIKIELAAAGTPIGPNDTAIAGHAISAKAILVTNNLREFERVPGLTLEDWVK

Download         Length: 417 bp

>T220993 NZ_CP117326:c4584092-4583781 [Salmonella enterica subsp. enterica serovar Newport]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8879.08 Da        Isoelectric Point: 4.8359

>AT220993 WP_039278475.1 NZ_CP085633:c3837365-3837138 [Pectobacterium brasiliense]
MRIVSVFKNGNNRAIRLPRDMDFEGVNELEIVREGDTIMLRPVKPNWHSFLQEDRADADFMTERQDVVEEGRFKL

Download         Length: 228 bp

>AT220993 NZ_CP117326:c4583780-4583490 [Salmonella enterica subsp. enterica serovar Newport]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7V8Q162

Antitoxin

Source ID Structure
AlphaFold DB A0A086EF97

References