Detailed information of TA system TA022099

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF-MazE
• Location: 3969507..3970078
• Replicon: chromosome
• Accession: NC_009483
• Organism: Geobacter uraniireducens Rf4

Toxin (Protein)

• Gene name: mazE
• Uniprot ID: A5G6W7
• Locus tag: GURA_RS17205
• Protein ID: WP_011940196.1
• Coordinates: 3969507..3969836 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: mazF
• Uniprot ID: A5G6W8
• Locus tag: GURA_RS17210
• Protein ID: WP_011940197.1
• Coordinates: 3969824..3970078 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GURA_RS17195	3964773..3966848	+	2076	WP_011940194.1	cache domain-containing protein	-
GURA_RS23015	3966918..3969245	-	2328	WP_011940195.1	PAS domain S-box protein	-
GURA_RS17205	3969507..3969836	-	330	WP_011940196.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
GURA_RS17210	3969824..3970078	-	255	WP_011940197.1	MazE family transcriptional regulator	Antitoxin
GURA_RS17215	3970216..3970539	+	324	Protein_3469	methyl-accepting chemotaxis protein	-
GURA_RS17220	3970901..3971683	-	783	WP_011940198.1	TIGR03915 family putative DNA repair protein	-
GURA_RS17225	3971680..3972966	-	1287	WP_011940199.1	putative DNA modification/repair radical SAM protein	-
GURA_RS17230	3973085..3973663	-	579	WP_011940200.1	Uma2 family endonuclease	-
GURA_RS17235	3973806..3973976	-	171	WP_011940201.1	twin-arginine translocase TatA/TatE family subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (6-107)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12365.53 Da
• Isoelectric Point: 10.1760

>T22099 WP_011940196.1 NC_009483:c3969836-3969507 [Geobacter uraniireducens Rf4]
MGMVIKRFDVYLVNLDPTVGSEIRKARPRIVISPDEMNRYIATVIVAPMTTKGRDYPTRVQCTFKGKGGQVVLDQIRTID
KSRLIQKLGRIDQQTQEEVLSILAEMFAP

Nucleotide

• Length: 330 bp

>T22099 NC_009483:c3969836-3969507 [Geobacter uraniireducens Rf4]
ATGGGAATGGTAATCAAACGATTCGATGTTTATCTGGTCAACTTGGACCCGACTGTCGGCAGTGAGATCCGCAAAGCCCG
GCCGCGTATCGTCATTTCGCCCGATGAGATGAACCGGTATATTGCTACCGTTATCGTAGCGCCAATGACGACCAAAGGCA
GGGATTATCCTACAAGAGTGCAGTGCACTTTCAAGGGCAAGGGTGGGCAAGTGGTCCTTGACCAAATCAGAACGATAGAC
AAATCGCGGCTTATTCAAAAGCTCGGGAGAATCGATCAACAGACGCAAGAAGAGGTTTTGTCGATTCTTGCTGAAATGTT
TGCGCCGTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9720.93 Da
• Isoelectric Point: 4.4442

>AT22099 WP_011940197.1 NC_009483:c3970078-3969824 [Geobacter uraniireducens Rf4]
MRTNIIRIGNSQGIRIPKVLLEQSHLGTEVELVVEDEKIVIRSASHPRQGWGEKFRLMAESGDDKMIDVDLSGETDWDKD
EWEW

Nucleotide

• Length: 255 bp

>AT22099 NC_009483:c3970078-3969824 [Geobacter uraniireducens Rf4]
ATGAGGACAAACATAATACGCATAGGAAATTCCCAAGGTATAAGGATTCCTAAAGTTCTCCTTGAACAGAGTCATCTTGG
AACGGAGGTGGAACTTGTGGTGGAAGATGAAAAAATAGTCATCCGCTCTGCGTCTCACCCCCGTCAAGGGTGGGGGGAAA
AATTTCGGCTCATGGCTGAGAGCGGCGACGATAAGATGATTGACGTGGATTTGAGCGGAGAAACAGACTGGGATAAGGAT
GAATGGGAATGGTAA

Structures

Toxin

• AlphaFold DB: A5G6W7

Antitoxin

• AlphaFold DB: A5G6W8