220988

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1207870..1208495 Replicon chromosome
Accession NZ_CP085633
Organism Pectobacterium brasiliense strain TS20HJ1

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag LJQ72_RS05340 Protein ID WP_005976087.1
Coordinates 1207870..1208073 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q6D809
Locus tag LJQ72_RS05345 Protein ID WP_010282247.1
Coordinates 1208127..1208495 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJQ72_RS05310 (LJQ72_05310) 1203201..1203539 + 339 WP_002208627.1 P-II family nitrogen regulator -
LJQ72_RS05315 (LJQ72_05315) 1203579..1204865 + 1287 WP_227527828.1 ammonium transporter AmtB -
LJQ72_RS05320 (LJQ72_05320) 1205007..1205870 - 864 WP_014914538.1 acyl-CoA thioesterase II -
LJQ72_RS05325 (LJQ72_05325) 1206083..1206664 + 582 WP_039284224.1 YbaY family lipoprotein -
LJQ72_RS05330 (LJQ72_05330) 1206684..1207004 - 321 WP_010282239.1 MGMT family protein -
LJQ72_RS05340 (LJQ72_05340) 1207870..1208073 - 204 WP_005976087.1 HHA domain-containing protein Toxin
LJQ72_RS05345 (LJQ72_05345) 1208127..1208495 - 369 WP_010282247.1 Hha toxicity modulator TomB Antitoxin
LJQ72_RS05350 (LJQ72_05350) 1209094..1209237 - 144 WP_005976091.1 type B 50S ribosomal protein L36 -
LJQ72_RS05355 (LJQ72_05355) 1209255..1209503 - 249 WP_039274617.1 type B 50S ribosomal protein L31 -
LJQ72_RS05360 (LJQ72_05360) 1209736..1212864 - 3129 WP_039466835.1 efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - acrB / acrA 1130887..1237105 106218


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T220988 WP_005976087.1 NZ_CP085633:c1208073-1207870 [Pectobacterium brasiliense]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T220988 NZ_CP117326:2022391-2022494 [Salmonella enterica subsp. enterica serovar Newport]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14046.80 Da        Isoelectric Point: 4.4787

>AT220988 WP_010282247.1 NZ_CP085633:c1208495-1208127 [Pectobacterium brasiliense]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENICTPAKT

Download         Length: 369 bp

>AT220988 NZ_CP117326:c2022496-2022351 [Salmonella enterica subsp. enterica serovar Newport]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A086EI31

References