Detailed information of TA system TA220982

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 429855..431499
• Replicon: chromosome
• Accession: NZ_CP085633
• Organism: Pectobacterium brasiliense strain TS20HJ1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: LJQ72_RS02000
• Protein ID: WP_227527612.1
• Coordinates: 430165..431499 (+)
• Length: 445 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LJQ72_RS01995
• Protein ID: WP_181846231.1
• Coordinates: 429855..430160 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJQ72_RS01970 (LJQ72_01970)	425395..426510	+	1116	WP_227527611.1	LPS export ABC transporter permease LptF	-
LJQ72_RS01975 (LJQ72_01975)	426510..427586	+	1077	WP_010284634.1	LPS export ABC transporter permease LptG	-
LJQ72_RS01985 (LJQ72_01985)	428122..429378	+	1257	Protein_380	tyrosine-type recombinase/integrase	-
LJQ72_RS01990 (LJQ72_01990)	429504..429710	-	207	WP_225181588.1	hypothetical protein	-
LJQ72_RS01995 (LJQ72_01995)	429855..430160	+	306	WP_181846231.1	helix-turn-helix transcriptional regulator	Antitoxin
LJQ72_RS02000 (LJQ72_02000)	430165..431499	+	1335	WP_227527612.1	type II toxin-antitoxin system HipA family toxin	Toxin
LJQ72_RS02005 (LJQ72_02005)	431775..432251	-	477	Protein_384	DNA primase	-
LJQ72_RS02010 (LJQ72_02010)	432232..432569	+	338	Protein_385	winged helix-turn-helix domain-containing protein	-
LJQ72_RS02015 (LJQ72_02015)	433351..436023	+	2673	WP_227527613.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (155-406)

Antitoxin

• Cro/C1-type helix-turn-helix domain (20-68)

Sequences

Toxin

Protein

• Length: 445 a.a.
• Molecular weight: 50742.86 Da
• Isoelectric Point: 6.0703

>T220982 WP_227527612.1 NZ_CP085633:430165-431499 [Pectobacterium brasiliense]
MPRTQQRLAIWMNGIQVGFWEKARGEDRLQYLPEWIADEQGRPLSLSLLFTPGNQIWRGNVVRDYFDNLLPDSEGIRRRL
ATRYHADSLEPFDLLAELGRDCVGAIQLLNGNEEPTDLFSVKYRPLCDAEIAAILRNTTAALLPGRQDDTDDLRLSIAGA
QEKTALLWHEGQWCLPEGSTPTTHIFKLPLGLVGNMQADMSTSVENEWLCSLILKEYGIPVAKTQIAQFEEQKALVVERF
DRRWSSDRQWIIRLPQEDMCQALGVSPLRKYQSDGGPGISDIMTILSHSEQAEQDKAQFFRAQIIFWLIAATDGHAKNFS
IAIEPQGRYHLTPLYDVLSAWPVIGPRNNQISWQKCKLAMAVRGSSNYYHLYRIKRRHWVNHGELTGLGRRQVEAMMDDI
ISRTPEVIERVSSLLPESFPPELAECVFDGMRQQCGRLQELQRK

Nucleotide

• Length: 1335 bp

>T220982 NZ_CP117322:c4651429-4651118 [Salmonella enterica subsp. enterica serovar Derby]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGTTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGTGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11258.97 Da
• Isoelectric Point: 10.3119

>AT220982 WP_181846231.1 NZ_CP085633:429855-430160 [Pectobacterium brasiliense]
MNTVYPLKTLNQLRPLLIGFRKAKGLTQKDVSERLGVTQQTYARLEANPGSASIERLFKVLTVLGVEVVLSSGPNVHFSM
SSSTMEEPEKPTDSPARREKW

Nucleotide

• Length: 306 bp

>AT220982 NZ_CP117322:c4651117-4650827 [Salmonella enterica subsp. enterica serovar Derby]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA