Detailed information of TA system TA220976

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4038686..4039346
• Replicon: chromosome
• Accession: NZ_CP085627
• Organism: Erwinia rhapontici strain BY21311

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: LJN55_RS18620
• Protein ID: WP_159337897.1
• Coordinates: 4038686..4039099 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: LJN55_RS18625
• Protein ID: WP_133846122.1
• Coordinates: 4039080..4039346 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJN55_RS18600 (LJN55_18600)	4034514..4035032	+	519	WP_227536411.1	flavodoxin FldB	-
LJN55_RS18605 (LJN55_18605)	4035129..4036490	-	1362	WP_227535024.1	cell envelope integrity protein CreD	-
LJN55_RS18610 (LJN55_18610)	4036580..4037998	-	1419	WP_133846119.1	two-component system sensor histidine kinase CreC	-
LJN55_RS18615 (LJN55_18615)	4037998..4038693	-	696	WP_133846120.1	two-component system response regulator CreB	-
LJN55_RS18620 (LJN55_18620)	4038686..4039099	-	414	WP_159337897.1	protein YgfX	Toxin
LJN55_RS18625 (LJN55_18625)	4039080..4039346	-	267	WP_133846122.1	FAD assembly factor SdhE	Antitoxin
LJN55_RS18630 (LJN55_18630)	4039573..4040559	+	987	WP_212813250.1	tRNA-modifying protein YgfZ	-
LJN55_RS18635 (LJN55_18635)	4040571..4041224	-	654	WP_133846124.1	hemolysin III family protein	-
LJN55_RS18640 (LJN55_18640)	4041437..4042045	+	609	WP_227535025.1	HD domain-containing protein	-
LJN55_RS18645 (LJN55_18645)	4042116..4042838	-	723	WP_133846126.1	class I SAM-dependent methyltransferase	-
LJN55_RS18650 (LJN55_18650)	4042884..4043639	+	756	WP_227535026.1	hydroxyacylglutathione hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-130)

Antitoxin

• Flavinator of succinate dehydrogenase (8-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16244.17 Da
• Isoelectric Point: 11.8917

>T220976 WP_159337897.1 NZ_CP085627:c4039099-4038686 [Erwinia rhapontici]
VVRWRCNLRASRRAQTLSLVLHGTLILALLLAPWPDSVSLPRILLLLLVLLECQCSRHRIRHCRGEITLHKGRVIVWAQC
QWRMTSRPWLTQRAIRLTLQNTAGRRERLWLFADGMDSSEWRLLRQHLLNEKEPRDE

Nucleotide

• Length: 414 bp

>T220976 NZ_CP117322:c2681543-2681440 [Salmonella enterica subsp. enterica serovar Derby]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10414.85 Da
• Isoelectric Point: 4.6290

>AT220976 WP_133846122.1 NZ_CP085627:c4039346-4039080 [Erwinia rhapontici]
MDISNKSRIHWACRRGMRELDISIMPFFQYEFDSLTDEDKQLFVRLLESDDPDLFNWLMNHGEPADAELQRMVALIQDRN
RARGPVAM

Nucleotide

• Length: 267 bp

>AT220976 NZ_CP117322:2681438-2681581 [Salmonella enterica subsp. enterica serovar Derby]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG