Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 906800..907434 Replicon chromosome
Accession NZ_CP085627
Organism Erwinia rhapontici strain BY21311

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LJN55_RS04150 Protein ID WP_133846148.1
Coordinates 906800..907075 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LJN55_RS04155 Protein ID WP_133846149.1
Coordinates 907072..907434 (+) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJN55_RS04135 (LJN55_04135) 903691..904323 - 633 WP_200641251.1 TetR/AcrR family transcriptional regulator -
LJN55_RS04140 (LJN55_04140) 904608..905828 + 1221 WP_212813749.1 Tm-1-like ATP-binding domain-containing protein -
LJN55_RS04145 (LJN55_04145) 905831..906661 + 831 WP_133846147.1 phosphoenolpyruvate hydrolase family protein -
LJN55_RS04150 (LJN55_04150) 906800..907075 + 276 WP_133846148.1 type II toxin-antitoxin system HicA family toxin Toxin
LJN55_RS04155 (LJN55_04155) 907072..907434 + 363 WP_133846149.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LJN55_RS04160 (LJN55_04160) 907482..908561 - 1080 WP_133846150.1 membrane-bound lytic murein transglycosylase MltC -
LJN55_RS04165 (LJN55_04165) 908616..908888 - 273 WP_133846151.1 oxidative damage protection protein -
LJN55_RS04170 (LJN55_04170) 908888..909973 - 1086 WP_227535745.1 A/G-specific adenine glycosylase -
LJN55_RS04175 (LJN55_04175) 910295..911014 + 720 WP_227535746.1 tRNA (guanosine(46)-N7)-methyltransferase TrmB -
LJN55_RS04180 (LJN55_04180) 911014..911340 + 327 WP_133846154.1 YggL family protein -
LJN55_RS04185 (LJN55_04185) 911493..912209 + 717 WP_133846155.1 DUF2884 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-88)

Antitoxin

Uncharacterised protein family HicB

(61-113)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10491.13 Da        Isoelectric Point: 11.6228

>T220971 WP_133846148.1 NZ_CP085627:906800-907075 [Erwinia rhapontici]
MRNRIAALRKRHRDTLRQIFTRPIPTDLKWQRIETLIIALGGEVREAQGSRVRFLLNGSLARFHRPHPSPETDKGAVVAV
KEWLEETGVEP

Download         Length: 276 bp

>T220971 NZ_CP117318:41573-41725 [Salmonella enterica subsp. enterica serovar Derby]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 13065.95 Da        Isoelectric Point: 4.8497

>AT220971 WP_133846149.1 NZ_CP085627:907072-907434 [Erwinia rhapontici]
MNKVMAIPNVMVIGGQPAAVNFVAELGAFRGKFLGLSGYCDFVADSITGLKCEGEISLRDYLADCHESGIDPYEHEEKVK
TFTLRYPESFGEQLAQAAAEHQLSLNSYIVAALSAQMKKC

Download         Length: 363 bp

>AT220971 NZ_CP117318:c41518-41461 [Salmonella enterica subsp. enterica serovar Derby]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References