Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 2166833..2167461 Replicon chromosome
Accession NC_009483
Organism Geobacter uraniireducens Rf4

Toxin (Protein)


Gene name vapC Uniprot ID A5GF53
Locus tag GURA_RS09465 Protein ID WP_011938761.1
Coordinates 2167060..2167461 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A5GF52
Locus tag GURA_RS09460 Protein ID WP_011938760.1
Coordinates 2166833..2167060 (+) Length 76 a.a.

Genomic Context

GURA_RS24240GURA_RS09445GURA_RS09450GURA_RS09455GURA_RS09460GURA_RS09465GURA_RS09470GURA_RS09475
Location: 2162371..2162439 (69 bp)
Type: Others
Protein ID: Protein_1902
Location: 2162556..2165804 (3249 bp)
Type: Others
Protein ID: WP_011938757.1
Location: 2165916..2166392 (477 bp)
Type: Others
Protein ID: WP_011938758.1
Location: 2166486..2166683 (198 bp)
Type: Others
Protein ID: WP_011938759.1
Location: 2166833..2167060 (228 bp)
Type: Antitoxin
Protein ID: WP_011938760.1
Location: 2167060..2167461 (402 bp)
Type: Toxin
Protein ID: WP_011938761.1
Location: 2168035..2170326 (2292 bp)
Type: Others
Protein ID: WP_041245875.1
Location: 2170404..2171471 (1068 bp)
Type: Others
Protein ID: WP_011938763.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GURA_RS242402162371..2162439+69Protein_1902SEC-C domain-containing protein-
GURA_RS094452162556..2165804+3249WP_011938757.1carbamoyl-phosphate synthase large subunit-
GURA_RS094502165916..2166392+477WP_011938758.1transcription elongation factor GreA-
GURA_RS094552166486..2166683+198WP_011938759.1DUF1858 domain-containing protein-
GURA_RS094602166833..2167060+228WP_011938760.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
GURA_RS094652167060..2167461+402WP_011938761.1type II toxin-antitoxin system VapC family toxinToxin
GURA_RS094702168035..2170326+2292WP_041245875.1ATP-dependent DNA helicase RecG-
GURA_RS094752170404..2171471-1068WP_011938763.1low specificity L-threonine aldolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14716.05 Da        Isoelectric Point: 5.1512

>T22097 WP_011938761.1 NC_009483:2167060-2167461 [Geobacter uraniireducens Rf4]
MKLLLDTNICIYIIKQQPATVLNRFLEYQVGDIGITSITLSELRYGVAKSTHREKNAKALDEFIIPLEVVSFDEEAAHVY
GDIRATLEKAGTPIGSMDMLIAAHAVSLGISLVTNNTREFVRIPALNIIDWTA

Download         Length: 402 bp

>T22097 NC_009483:2167060-2167461 [Geobacter uraniireducens Rf4]
ATGAAACTGTTGCTCGATACCAATATCTGCATTTACATTATCAAGCAACAGCCAGCAACCGTGCTCAATCGTTTTCTTGA
ATATCAGGTTGGCGACATAGGCATTACTTCTATTACCCTTTCAGAATTGCGCTATGGAGTTGCCAAGAGCACACATCGCG
AAAAAAATGCCAAAGCCCTTGATGAGTTTATTATCCCTTTAGAAGTAGTCTCTTTCGATGAAGAGGCGGCTCATGTTTAC
GGTGACATTCGAGCAACTCTGGAAAAGGCAGGCACACCCATCGGTTCCATGGATATGCTTATTGCTGCTCATGCCGTATC
TTTAGGAATTTCCCTGGTAACTAACAACACCCGCGAATTCGTACGCATCCCCGCCCTCAATATTATCGATTGGACAGCCT
AG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8780.08 Da        Isoelectric Point: 10.5623

>AT22097 WP_011938760.1 NC_009483:2166833-2167060 [Geobacter uraniireducens Rf4]
MKTAKIFQNGQSQAVRLPKEFRFDDSEVFIKKTGNVVQLIPRSDSWNSLFGSLKKFSRDFMVERVQPELDKRESL

Download         Length: 228 bp

>AT22097 NC_009483:2166833-2167060 [Geobacter uraniireducens Rf4]
ATGAAAACAGCAAAGATATTTCAAAATGGACAAAGTCAGGCTGTCAGGCTTCCAAAAGAGTTTCGCTTCGACGACAGCGA
AGTCTTCATTAAAAAGACAGGCAACGTCGTACAGTTGATTCCCCGTAGCGATTCGTGGAATTCACTATTTGGCAGCCTCA
AAAAGTTTTCCCGCGATTTCATGGTTGAACGCGTACAGCCCGAACTGGACAAGCGGGAGAGTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA5GF53

Antitoxin

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Source
ID
Structure
AlphaFold DBA5GF52

References