Detailed information of TA system TA022097

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-MazE
• Location: 2166833..2167461
• Replicon: chromosome
• Accession: NC_009483
• Organism: Geobacter uraniireducens Rf4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A5GF53
• Locus tag: GURA_RS09465
• Protein ID: WP_011938761.1
• Coordinates: 2167060..2167461 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A5GF52
• Locus tag: GURA_RS09460
• Protein ID: WP_011938760.1
• Coordinates: 2166833..2167060 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GURA_RS24240	2162371..2162439	+	69	Protein_1902	SEC-C domain-containing protein	-
GURA_RS09445	2162556..2165804	+	3249	WP_011938757.1	carbamoyl-phosphate synthase large subunit	-
GURA_RS09450	2165916..2166392	+	477	WP_011938758.1	transcription elongation factor GreA	-
GURA_RS09455	2166486..2166683	+	198	WP_011938759.1	DUF1858 domain-containing protein	-
GURA_RS09460	2166833..2167060	+	228	WP_011938760.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
GURA_RS09465	2167060..2167461	+	402	WP_011938761.1	type II toxin-antitoxin system VapC family toxin	Toxin
GURA_RS09470	2168035..2170326	+	2292	WP_041245875.1	ATP-dependent DNA helicase RecG	-
GURA_RS09475	2170404..2171471	-	1068	WP_011938763.1	low specificity L-threonine aldolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (7-53)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14716.05 Da
• Isoelectric Point: 5.1512

>T22097 WP_011938761.1 NC_009483:2167060-2167461 [Geobacter uraniireducens Rf4]
MKLLLDTNICIYIIKQQPATVLNRFLEYQVGDIGITSITLSELRYGVAKSTHREKNAKALDEFIIPLEVVSFDEEAAHVY
GDIRATLEKAGTPIGSMDMLIAAHAVSLGISLVTNNTREFVRIPALNIIDWTA

Nucleotide

• Length: 402 bp

>T22097 NC_009483:2167060-2167461 [Geobacter uraniireducens Rf4]
ATGAAACTGTTGCTCGATACCAATATCTGCATTTACATTATCAAGCAACAGCCAGCAACCGTGCTCAATCGTTTTCTTGA
ATATCAGGTTGGCGACATAGGCATTACTTCTATTACCCTTTCAGAATTGCGCTATGGAGTTGCCAAGAGCACACATCGCG
AAAAAAATGCCAAAGCCCTTGATGAGTTTATTATCCCTTTAGAAGTAGTCTCTTTCGATGAAGAGGCGGCTCATGTTTAC
GGTGACATTCGAGCAACTCTGGAAAAGGCAGGCACACCCATCGGTTCCATGGATATGCTTATTGCTGCTCATGCCGTATC
TTTAGGAATTTCCCTGGTAACTAACAACACCCGCGAATTCGTACGCATCCCCGCCCTCAATATTATCGATTGGACAGCCT
AG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8780.08 Da
• Isoelectric Point: 10.5623

>AT22097 WP_011938760.1 NC_009483:2166833-2167060 [Geobacter uraniireducens Rf4]
MKTAKIFQNGQSQAVRLPKEFRFDDSEVFIKKTGNVVQLIPRSDSWNSLFGSLKKFSRDFMVERVQPELDKRESL

Nucleotide

• Length: 228 bp

>AT22097 NC_009483:2166833-2167060 [Geobacter uraniireducens Rf4]
ATGAAAACAGCAAAGATATTTCAAAATGGACAAAGTCAGGCTGTCAGGCTTCCAAAAGAGTTTCGCTTCGACGACAGCGA
AGTCTTCATTAAAAAGACAGGCAACGTCGTACAGTTGATTCCCCGTAGCGATTCGTGGAATTCACTATTTGGCAGCCTCA
AAAAGTTTTCCCGCGATTTCATGGTTGAACGCGTACAGCCCGAACTGGACAAGCGGGAGAGTTTGTGA

Structures

Toxin

• AlphaFold DB: A5GF53

Antitoxin

• AlphaFold DB: A5GF52