Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1719577..1721154 Replicon chromosome
Accession NC_009483
Organism Geobacter uraniireducens Rf4

Toxin (Protein)


Gene name hipA Uniprot ID A5GE21
Locus tag GURA_RS07520 Protein ID WP_011938391.1
Coordinates 1719829..1721154 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag GURA_RS07515 Protein ID WP_041245339.1
Coordinates 1719577..1719828 (+) Length 84 a.a.

Genomic Context

GURA_RS07515GURA_RS07520GURA_RS23320GURA_RS07525GURA_RS07530GURA_RS07535
Location: 1719577..1719828 (252 bp)
Type: Antitoxin
Protein ID: WP_041245339.1
Location: 1719829..1721154 (1326 bp)
Type: Toxin
Protein ID: WP_011938391.1
Location: 1721461..1721592 (132 bp)
Type: Others
Protein ID: WP_083764810.1
Location: 1721663..1721920 (258 bp)
Type: Others
Protein ID: WP_011938392.1
Location: 1721914..1722315 (402 bp)
Type: Others
Protein ID: WP_011938393.1
Location: 1722764..1725097 (2334 bp)
Type: Others
Protein ID: WP_011938394.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GURA_RS075151719577..1719828+252WP_041245339.1helix-turn-helix domain-containing proteinAntitoxin
GURA_RS075201719829..1721154+1326WP_011938391.1type II toxin-antitoxin system HipA family toxinToxin
GURA_RS233201721461..1721592+132WP_083764810.1hypothetical protein-
GURA_RS075251721663..1721920+258WP_011938392.1AbrB/MazE/SpoVT family DNA-binding domain-containing protein-
GURA_RS075301721914..1722315+402WP_011938393.1type II toxin-antitoxin system PemK/MazF family toxin-
GURA_RS075351722764..1725097+2334WP_011938394.1type I restriction-modification system subunit M-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-66)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 49686.17 Da        Isoelectric Point: 7.4110

>T22096 WP_011938391.1 NC_009483:1719829-1721154 [Geobacter uraniireducens Rf4]
MSRTRLSSDLHVFMNGRTVGRLTRTSSGKLQFSYCEEWLSWELGRPLSLSMPMTQEPYAGEVVENYFDNLLPDSQSIRNR
IQARFAARSNRCFDLLWHAGRDCVGALQLIPENAGPLDVHKVESVPLSDAEIADTLRNYQTMPLGMGRESDFRISIAGAQ
EKTALLLLDGRWCRPLGVTPTSHIFKLPIGTIAHSGMDLTDSVENEWLCHLILKGYGLPVANAEIRTFDGVKVLVVERFD
RRWAEDRSWLIRLPQEDMCQALGVPPALKYESDGGPGSERIMNLLLGSAEGLRDRKMFMTLQVLFWLLAAIDGHAKNFSI
FLLPGGSYRLTPAYDIMSAYPPVAKRQLELQSLKMAMAVKGKTSHYQWTRISYRHWLSTAVRCRFSAEEMAIIITELLER
MDDVIAAVSGQLPQSFPEGVSEAIFDGMRNARDRLVRSRTA

Download         Length: 1326 bp

>T22096 NC_009483:1719829-1721154 [Geobacter uraniireducens Rf4]
ATGTCACGAACTCGTCTATCATCTGACCTGCATGTTTTCATGAATGGCCGAACGGTTGGCCGTCTGACTCGGACTTCCAG
CGGGAAGCTCCAGTTTTCCTATTGCGAAGAGTGGTTGAGTTGGGAACTTGGCCGCCCTTTGTCCCTTTCCATGCCCATGA
CCCAGGAGCCTTACGCCGGGGAGGTTGTGGAGAATTATTTCGACAACCTCCTGCCAGATAGTCAATCGATCAGAAATCGC
ATTCAAGCCAGGTTTGCAGCCCGGTCAAACCGTTGCTTTGACCTGTTGTGGCATGCGGGAAGGGATTGCGTTGGCGCCCT
GCAACTCATCCCTGAAAATGCAGGACCACTCGATGTGCACAAGGTCGAGTCGGTACCCTTGAGTGACGCTGAGATTGCCG
ATACGCTCCGTAACTATCAAACCATGCCATTAGGAATGGGGAGAGAGAGCGATTTCCGCATTTCCATCGCCGGGGCGCAG
GAAAAGACCGCCCTGCTGTTGCTGGATGGCAGGTGGTGCCGCCCGTTGGGCGTTACCCCTACCAGTCATATTTTCAAACT
GCCCATCGGCACAATTGCTCACAGCGGTATGGACTTGACCGACAGCGTCGAAAACGAATGGCTTTGCCATCTGATTTTGA
AAGGCTACGGTCTGCCCGTGGCAAATGCGGAGATCAGGACGTTCGATGGGGTTAAGGTTCTCGTGGTGGAACGTTTCGAC
CGGCGCTGGGCTGAGGACCGGTCGTGGCTGATACGGCTGCCACAGGAAGACATGTGCCAGGCGCTGGGTGTGCCGCCGGC
ATTGAAGTACGAAAGTGACGGTGGGCCGGGTAGCGAAAGAATCATGAATCTTCTTCTCGGTTCGGCTGAAGGTTTGCGCG
ACCGGAAGATGTTCATGACGCTGCAGGTGCTGTTCTGGCTATTGGCGGCAATAGACGGCCATGCAAAGAATTTCAGTATC
TTCCTGTTGCCGGGAGGCAGTTATCGGCTCACCCCGGCGTATGACATCATGTCGGCATACCCGCCTGTAGCAAAACGTCA
ACTTGAGTTGCAAAGCCTGAAAATGGCCATGGCCGTCAAAGGGAAAACCAGCCATTACCAGTGGACGAGAATCAGTTACC
GGCATTGGCTCTCCACGGCAGTGCGGTGCAGATTTTCTGCAGAAGAAATGGCGATCATTATAACTGAACTTCTGGAGCGG
ATGGACGATGTCATTGCTGCGGTTTCAGGGCAGTTGCCGCAATCCTTCCCCGAAGGGGTAAGCGAGGCTATTTTTGATGG
GATGCGTAACGCTCGGGATCGTTTGGTGCGTTCACGAACTGCATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9116.49 Da        Isoelectric Point: 10.5623

>AT22096 WP_041245339.1 NC_009483:1719577-1719828 [Geobacter uraniireducens Rf4]
MTQKILSPESLGAALRKERKKKGLSQTDVGKSVGIDQPTISRVEKGNPGTELATLFRLLAALDLELKIQSRQQLANDTRG
DVW

Download         Length: 252 bp

>AT22096 NC_009483:1719577-1719828 [Geobacter uraniireducens Rf4]
ATGACGCAGAAAATCCTTTCTCCCGAGAGTCTCGGAGCTGCATTGCGTAAAGAGCGCAAGAAGAAAGGGCTGAGCCAGAC
CGACGTCGGCAAATCGGTCGGTATTGACCAGCCAACAATATCGAGGGTTGAAAAGGGGAATCCCGGGACGGAATTGGCGA
CTCTCTTCCGACTGTTGGCAGCGCTCGATCTGGAACTGAAAATTCAATCACGGCAACAATTGGCTAACGACACAAGAGGA
GACGTTTGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA5GE21

Antitoxin

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Source
ID
Structure
No matching records found

References