Detailed information of TA system TA022096

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1719577..1721154
• Replicon: chromosome
• Accession: NC_009483
• Organism: Geobacter uraniireducens Rf4

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A5GE21
• Locus tag: GURA_RS07520
• Protein ID: WP_011938391.1
• Coordinates: 1719829..1721154 (+)
• Length: 442 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: GURA_RS07515
• Protein ID: WP_041245339.1
• Coordinates: 1719577..1719828 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GURA_RS07515	1719577..1719828	+	252	WP_041245339.1	helix-turn-helix domain-containing protein	Antitoxin
GURA_RS07520	1719829..1721154	+	1326	WP_011938391.1	type II toxin-antitoxin system HipA family toxin	Toxin
GURA_RS23320	1721461..1721592	+	132	WP_083764810.1	hypothetical protein	-
GURA_RS07525	1721663..1721920	+	258	WP_011938392.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
GURA_RS07530	1721914..1722315	+	402	WP_011938393.1	type II toxin-antitoxin system PemK/MazF family toxin	-
GURA_RS07535	1722764..1725097	+	2334	WP_011938394.1	type I restriction-modification system subunit M	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (10-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-66)

Sequences

Toxin

Protein

• Length: 442 a.a.
• Molecular weight: 49686.17 Da
• Isoelectric Point: 7.4110

>T22096 WP_011938391.1 NC_009483:1719829-1721154 [Geobacter uraniireducens Rf4]
MSRTRLSSDLHVFMNGRTVGRLTRTSSGKLQFSYCEEWLSWELGRPLSLSMPMTQEPYAGEVVENYFDNLLPDSQSIRNR
IQARFAARSNRCFDLLWHAGRDCVGALQLIPENAGPLDVHKVESVPLSDAEIADTLRNYQTMPLGMGRESDFRISIAGAQ
EKTALLLLDGRWCRPLGVTPTSHIFKLPIGTIAHSGMDLTDSVENEWLCHLILKGYGLPVANAEIRTFDGVKVLVVERFD
RRWAEDRSWLIRLPQEDMCQALGVPPALKYESDGGPGSERIMNLLLGSAEGLRDRKMFMTLQVLFWLLAAIDGHAKNFSI
FLLPGGSYRLTPAYDIMSAYPPVAKRQLELQSLKMAMAVKGKTSHYQWTRISYRHWLSTAVRCRFSAEEMAIIITELLER
MDDVIAAVSGQLPQSFPEGVSEAIFDGMRNARDRLVRSRTA

Nucleotide

• Length: 1326 bp

>T22096 NC_009483:1719829-1721154 [Geobacter uraniireducens Rf4]
ATGTCACGAACTCGTCTATCATCTGACCTGCATGTTTTCATGAATGGCCGAACGGTTGGCCGTCTGACTCGGACTTCCAG
CGGGAAGCTCCAGTTTTCCTATTGCGAAGAGTGGTTGAGTTGGGAACTTGGCCGCCCTTTGTCCCTTTCCATGCCCATGA
CCCAGGAGCCTTACGCCGGGGAGGTTGTGGAGAATTATTTCGACAACCTCCTGCCAGATAGTCAATCGATCAGAAATCGC
ATTCAAGCCAGGTTTGCAGCCCGGTCAAACCGTTGCTTTGACCTGTTGTGGCATGCGGGAAGGGATTGCGTTGGCGCCCT
GCAACTCATCCCTGAAAATGCAGGACCACTCGATGTGCACAAGGTCGAGTCGGTACCCTTGAGTGACGCTGAGATTGCCG
ATACGCTCCGTAACTATCAAACCATGCCATTAGGAATGGGGAGAGAGAGCGATTTCCGCATTTCCATCGCCGGGGCGCAG
GAAAAGACCGCCCTGCTGTTGCTGGATGGCAGGTGGTGCCGCCCGTTGGGCGTTACCCCTACCAGTCATATTTTCAAACT
GCCCATCGGCACAATTGCTCACAGCGGTATGGACTTGACCGACAGCGTCGAAAACGAATGGCTTTGCCATCTGATTTTGA
AAGGCTACGGTCTGCCCGTGGCAAATGCGGAGATCAGGACGTTCGATGGGGTTAAGGTTCTCGTGGTGGAACGTTTCGAC
CGGCGCTGGGCTGAGGACCGGTCGTGGCTGATACGGCTGCCACAGGAAGACATGTGCCAGGCGCTGGGTGTGCCGCCGGC
ATTGAAGTACGAAAGTGACGGTGGGCCGGGTAGCGAAAGAATCATGAATCTTCTTCTCGGTTCGGCTGAAGGTTTGCGCG
ACCGGAAGATGTTCATGACGCTGCAGGTGCTGTTCTGGCTATTGGCGGCAATAGACGGCCATGCAAAGAATTTCAGTATC
TTCCTGTTGCCGGGAGGCAGTTATCGGCTCACCCCGGCGTATGACATCATGTCGGCATACCCGCCTGTAGCAAAACGTCA
ACTTGAGTTGCAAAGCCTGAAAATGGCCATGGCCGTCAAAGGGAAAACCAGCCATTACCAGTGGACGAGAATCAGTTACC
GGCATTGGCTCTCCACGGCAGTGCGGTGCAGATTTTCTGCAGAAGAAATGGCGATCATTATAACTGAACTTCTGGAGCGG
ATGGACGATGTCATTGCTGCGGTTTCAGGGCAGTTGCCGCAATCCTTCCCCGAAGGGGTAAGCGAGGCTATTTTTGATGG
GATGCGTAACGCTCGGGATCGTTTGGTGCGTTCACGAACTGCATGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9116.49 Da
• Isoelectric Point: 10.5623

>AT22096 WP_041245339.1 NC_009483:1719577-1719828 [Geobacter uraniireducens Rf4]
MTQKILSPESLGAALRKERKKKGLSQTDVGKSVGIDQPTISRVEKGNPGTELATLFRLLAALDLELKIQSRQQLANDTRG
DVW

Nucleotide

• Length: 252 bp

>AT22096 NC_009483:1719577-1719828 [Geobacter uraniireducens Rf4]
ATGACGCAGAAAATCCTTTCTCCCGAGAGTCTCGGAGCTGCATTGCGTAAAGAGCGCAAGAAGAAAGGGCTGAGCCAGAC
CGACGTCGGCAAATCGGTCGGTATTGACCAGCCAACAATATCGAGGGTTGAAAAGGGGAATCCCGGGACGGAATTGGCGA
CTCTCTTCCGACTGTTGGCAGCGCTCGATCTGGAACTGAAAATTCAATCACGGCAACAATTGGCTAACGACACAAGAGGA
GACGTTTGGTAG

Structures

Toxin

• AlphaFold DB: A5GE21