Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3632110..3632945 Replicon chromosome
Accession NZ_CP085622
Organism Escherichia coli strain EC71

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7W4PV54
Locus tag LJN53_RS17630 Protein ID WP_000854821.1
Coordinates 3632110..3632487 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M0D404
Locus tag LJN53_RS17635 Protein ID WP_024214935.1
Coordinates 3632577..3632945 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJN53_RS17600 (3627663) 3627663..3628619 + 957 WP_000121354.1 molybdenum cofactor insertion chaperone PaoD -
LJN53_RS17605 (3628670) 3628670..3629008 + 339 Protein_3440 LysR substrate-binding domain-containing protein -
LJN53_RS17610 (3629346) 3629346..3630665 + 1320 WP_000144688.1 site-specific integrase -
LJN53_RS17615 (3630758) 3630758..3631606 - 849 WP_001280470.1 DUF4942 domain-containing protein -
LJN53_RS17620 (3631691) 3631691..3631888 - 198 WP_089075429.1 DUF957 domain-containing protein -
LJN53_RS17625 (3631916) 3631916..3632113 - 198 Protein_3444 DUF5983 family protein -
LJN53_RS17630 (3632110) 3632110..3632487 - 378 WP_000854821.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
LJN53_RS17635 (3632577) 3632577..3632945 - 369 WP_024214935.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LJN53_RS17640 (3633025) 3633025..3633246 - 222 WP_000692350.1 DUF987 domain-containing protein -
LJN53_RS17645 (3633333) 3633333..3633809 - 477 WP_001186745.1 RadC family protein -
LJN53_RS17650 (3633825) 3633825..3634310 - 486 WP_024214936.1 antirestriction protein -
LJN53_RS17655 (3634402) 3634402..3635220 - 819 WP_001234397.1 DUF932 domain-containing protein -
LJN53_RS17660 (3635310) 3635310..3635543 - 234 WP_001117566.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13930.95 Da        Isoelectric Point: 8.5163

>T220955 WP_000854821.1 NZ_CP085622:c3632487-3632110 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T220955 NZ_CP117312:3209707-3209991 [Salmonella enterica subsp. enterica serovar Derby]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13605.41 Da        Isoelectric Point: 6.4659

>AT220955 WP_024214935.1 NZ_CP085622:c3632945-3632577 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT220955 NZ_CP117312:3209469-3209717 [Salmonella enterica subsp. enterica serovar Derby]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W4PV54

Antitoxin

Source ID Structure
AlphaFold DB A0A1M0D404

References