Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1847340..1848175 Replicon chromosome
Accession NZ_CP085622
Organism Escherichia coli strain EC71

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1U9SHU4
Locus tag LJN53_RS08865 Protein ID WP_000854752.1
Coordinates 1847340..1847717 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E3PJ72
Locus tag LJN53_RS08870 Protein ID WP_001278232.1
Coordinates 1847807..1848175 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJN53_RS08830 (1842860) 1842860..1843333 + 474 WP_001105384.1 DNA gyrase inhibitor SbmC -
LJN53_RS08835 (1843531) 1843531..1844589 + 1059 WP_001200892.1 FUSC family protein -
LJN53_RS08840 (1844761) 1844761..1845090 + 330 WP_000450409.1 DUF496 family protein -
LJN53_RS08845 (1845191) 1845191..1845556 - 366 WP_001282181.1 EutP/PduV family microcompartment system protein -
LJN53_RS08850 (1845827) 1845827..1846216 - 390 WP_001445118.1 IS110 family transposase -
LJN53_RS08855 (1847014) 1847014..1847094 - 81 Protein_1725 hypothetical protein -
LJN53_RS08860 (1847194) 1847194..1847343 - 150 Protein_1726 DUF5983 family protein -
LJN53_RS08865 (1847340) 1847340..1847717 - 378 WP_000854752.1 TA system toxin CbtA family protein Toxin
LJN53_RS08870 (1847807) 1847807..1848175 - 369 WP_001278232.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
LJN53_RS08875 (1848338) 1848338..1848559 - 222 WP_000692329.1 DUF987 domain-containing protein -
LJN53_RS08880 (1848622) 1848622..1849098 - 477 WP_001347688.1 RadC family protein -
LJN53_RS08885 (1849114) 1849114..1849599 - 486 WP_000849582.1 antirestriction protein -
LJN53_RS08890 (1849654) 1849654..1850472 - 819 WP_001234620.1 DUF932 domain-containing protein -
LJN53_RS08895 (1850572) 1850572..1850805 - 234 WP_001119729.1 DUF905 family protein -
LJN53_RS08900 (1850884) 1850884..1851339 - 456 WP_000581504.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14076.08 Da        Isoelectric Point: 8.2905

>T220942 WP_000854752.1 NZ_CP085622:c1847717-1847340 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T220942 NZ_CP117307:4113606-4114022 [Salmonella enterica subsp. enterica serovar Derby]
ATGAGTAAAACCTACATGCTGGATACCTGCATCTGTTCTTTCATTATGCGCGAACAGCCGGAAGCTGTGCTGAAACGCCT
TGAGCAGGCAGTGCTGCGCCGCCATCGTATTGTGGTGTCGGCGATTACCTACGCCGAAATGCGTTTTGGCTGTACGGGCA
AAAAGGCCTCGCCGCGCCATGCCCAACTGGTTGATGCATTCTGTAGTCGCCTGGATGCCGTGCTGGCCTGGGACCGGGCG
GCAGTGGATGCCACCACAGAGATCCGTGCCGTACTGGCCGCCGCCGGTACGCCGATTGGATCAAACGATGCGGCTATCGC
CGGCCATGCCATTGCGTCCGGGGCGATACTGGTCACTAATAACGTGAGGGAGTTTGAGCGGGTACCGGGTTTGCAGTACG
AAGATTGGGTAAAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT220942 WP_001278232.1 NZ_CP085622:c1848175-1847807 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT220942 NZ_CP117307:4113379-4113609 [Salmonella enterica subsp. enterica serovar Derby]
ATGCGAACCGTATCTGTATTTAAAAATGGCAATAACCGCGCGATCCGCCTTCCACGCGATCTGGATTTTGACGGCGTCAA
CGAACTTGAAATCTTCCGCGAAGGCGACACGATTATACTGCGCCCCGCCCGCCCTTCCTGGGGATCATTCCGTCATGAGG
AAAAAGCCAGCCCAGACTTTCTGACGGAACGCGAAGACATCATCAGCGATGAGGGACGCTTTGAACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9SHU4

Antitoxin

Source ID Structure
AlphaFold DB E3PJ72

References