Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 867173..867827 Replicon chromosome
Accession NZ_CP085622
Organism Escherichia coli strain EC71

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag LJN53_RS04240 Protein ID WP_000244772.1
Coordinates 867420..867827 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag LJN53_RS04235 Protein ID WP_063100142.1
Coordinates 867173..867439 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJN53_RS04210 (862461) 862461..863204 + 744 WP_000951964.1 SDR family oxidoreductase -
LJN53_RS04215 (863261) 863261..864694 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
LJN53_RS04220 (864739) 864739..865050 + 312 WP_001182944.1 N(4)-acetylcytidine aminohydrolase -
LJN53_RS04225 (865214) 865214..865873 + 660 WP_000250274.1 hemolysin III family protein -
LJN53_RS04230 (865950) 865950..866930 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
LJN53_RS04235 (867173) 867173..867439 + 267 WP_063100142.1 FAD assembly factor SdhE Antitoxin
LJN53_RS04240 (867420) 867420..867827 + 408 WP_000244772.1 protein YgfX Toxin
LJN53_RS04245 (867867) 867867..868388 - 522 WP_001055874.1 flavodoxin FldB -
LJN53_RS04250 (868500) 868500..869396 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
LJN53_RS04255 (869421) 869421..870131 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LJN53_RS04260 (870137) 870137..871870 + 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T220938 WP_000244772.1 NZ_CP085622:867420-867827 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T220938 NZ_CP117307:c2669062-2668959 [Salmonella enterica subsp. enterica serovar Derby]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10548.07 Da        Isoelectric Point: 5.1599

>AT220938 WP_063100142.1 NZ_CP085622:867173-867439 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFNRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT220938 NZ_CP117307:2668957-2669100 [Salmonella enterica subsp. enterica serovar Derby]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure

References