Detailed information of TA system TA022093

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1435232..1435823
• Replicon: chromosome
• Accession: NC_009483
• Organism: Geobacter uraniireducens Rf4

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: GURA_RS23285
• Protein ID: WP_083764790.1
• Coordinates: 1435635..1435823 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A5GAH3
• Locus tag: GURA_RS06220
• Protein ID: WP_011938144.1
• Coordinates: 1435232..1435633 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GURA_RS06200	1430894..1431583	+	690	WP_011938140.1	type 1 glutamine amidotransferase	-
GURA_RS06205	1431721..1432002	+	282	WP_011938141.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GURA_RS06210	1432013..1432318	+	306	WP_011938142.1	HigA family addiction module antidote protein	-
GURA_RS24140	1433131..1433817	+	687	WP_157046138.1	hypothetical protein	-
GURA_RS06215	1434056..1434916	+	861	WP_041245790.1	AraC family transcriptional regulator	-
GURA_RS06220	1435232..1435633	-	402	WP_011938144.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GURA_RS23285	1435635..1435823	-	189	WP_083764790.1	type II toxin-antitoxin system HicA family toxin	Toxin
GURA_RS06225	1436011..1438290	-	2280	WP_011938145.1	metallophosphoesterase	-
GURA_RS06230	1438690..1440144	+	1455	WP_011938146.1	ribonuclease HI	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-123)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7173.25 Da
• Isoelectric Point: 10.4807

>T22093 WP_083764790.1 NC_009483:c1435823-1435635 [Geobacter uraniireducens Rf4]
MTSKEIIKRLENEGWCCVGGKGDHQKHKHPSKAGHVVVPHPRKDMPTGTLRNIYRQAGWEWR

Nucleotide

• Length: 189 bp

>T22093 NC_009483:c1435823-1435635 [Geobacter uraniireducens Rf4]
ATGACCAGCAAAGAGATCATCAAACGACTTGAAAACGAGGGATGGTGTTGTGTCGGAGGCAAAGGTGACCACCAGAAGCA
CAAACATCCGTCAAAAGCTGGTCATGTGGTAGTGCCACATCCACGTAAAGACATGCCAACCGGAACCTTGCGGAACATTT
ACCGGCAAGCTGGTTGGGAATGGAGATAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 15019.92 Da
• Isoelectric Point: 4.5198

>AT22093 WP_011938144.1 NC_009483:c1435633-1435232 [Geobacter uraniireducens Rf4]
MLYPAYVHIGDDQHAHGVTIPDFPGCFSAADEWEDLPHMIQEAAEVYFEGEDMPVPAPTPLEQLAANPEYQGGVWLLVDI
DLSKLKVKAKRVNITMSENLLHEIDRYAEQYHMTRSGLLAQAADQYIHRKQSA

Nucleotide

• Length: 402 bp

>AT22093 NC_009483:c1435633-1435232 [Geobacter uraniireducens Rf4]
ATGTTATACCCCGCATATGTTCACATTGGAGACGATCAACACGCCCACGGAGTAACTATCCCCGACTTTCCCGGCTGTTT
CTCTGCCGCCGACGAGTGGGAGGATTTACCACACATGATCCAAGAGGCCGCAGAAGTCTATTTTGAAGGCGAAGATATGC
CTGTGCCTGCACCAACACCATTAGAACAATTGGCTGCTAACCCCGAATATCAAGGAGGGGTATGGCTCTTGGTAGACATT
GATCTTTCCAAGCTCAAAGTTAAAGCAAAGCGGGTTAATATAACCATGTCTGAAAATCTGCTGCATGAGATCGACCGTTA
TGCCGAGCAGTACCACATGACTCGTTCCGGTCTATTGGCCCAGGCTGCGGATCAATATATTCACCGCAAACAATCAGCGT
AA

Structures

Antitoxin

• AlphaFold DB: A5GAH3