Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 801580..802414 | Replicon | chromosome |
| Accession | NZ_CP085619 | ||
| Organism | Escherichia coli strain EC32 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1PLF5 |
| Locus tag | LJN50_RS03920 | Protein ID | WP_000854690.1 |
| Coordinates | 801580..801957 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1P7N8 |
| Locus tag | LJN50_RS03925 | Protein ID | WP_001305076.1 |
| Coordinates | 802046..802414 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJN50_RS03890 (797974) | 797974..798144 | - | 171 | Protein_764 | IS110 family transposase | - |
| LJN50_RS03895 (798561) | 798561..799494 | - | 934 | Protein_765 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| LJN50_RS03900 (799487) | 799487..799882 | - | 396 | WP_000208384.1 | DUF6088 family protein | - |
| LJN50_RS03905 (799951) | 799951..800796 | - | 846 | WP_001529401.1 | DUF4942 domain-containing protein | - |
| LJN50_RS03910 (800881) | 800881..801078 | - | 198 | WP_000839293.1 | DUF957 domain-containing protein | - |
| LJN50_RS03915 (801095) | 801095..801583 | - | 489 | WP_000761699.1 | DUF5983 family protein | - |
| LJN50_RS03920 (801580) | 801580..801957 | - | 378 | WP_000854690.1 | TA system toxin CbtA family protein | Toxin |
| LJN50_RS03925 (802046) | 802046..802414 | - | 369 | WP_001305076.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| LJN50_RS03930 (802464) | 802464..803108 | - | 645 | WP_000094916.1 | hypothetical protein | - |
| LJN50_RS03935 (803127) | 803127..803348 | - | 222 | WP_000692329.1 | DUF987 domain-containing protein | - |
| LJN50_RS03940 (803411) | 803411..803887 | - | 477 | WP_001186726.1 | RadC family protein | - |
| LJN50_RS03945 (803903) | 803903..804388 | - | 486 | WP_000849565.1 | antirestriction protein | - |
| LJN50_RS03950 (804443) | 804443..805261 | - | 819 | WP_001234620.1 | DUF932 domain-containing protein | - |
| LJN50_RS03955 (805362) | 805362..805595 | - | 234 | WP_000902034.1 | DUF905 family protein | - |
| LJN50_RS03960 (805674) | 805674..806129 | - | 456 | WP_000581502.1 | IrmA family protein | - |
| LJN50_RS03965 (806205) | 806205..807332 | - | 1128 | Protein_779 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 797974..798129 | 155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14057.04 Da Isoelectric Point: 9.1510
>T220911 WP_000854690.1 NZ_CP085619:c801957-801580 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
Download Length: 378 bp
>T220911 NZ_CP117301:351491-351766 [Salmonella enterica subsp. enterica serovar Derby]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATTACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGGGCCTGACTGGATTCTTATTGATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATTACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGGGCCTGACTGGATTCTTATTGATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13560.39 Da Isoelectric Point: 4.7830
>AT220911 WP_001305076.1 NZ_CP085619:c802414-802046 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN
Download Length: 369 bp
>AT220911 NZ_CP117301:351228-351488 [Salmonella enterica subsp. enterica serovar Derby]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGAATCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGGATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGACATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGAATCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGGATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGACATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|