220905

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 34959..36312 Replicon plasmid pAsa9-like
Accession NZ_CP085535
Organism Aeromonas salmonicida subsp. salmonicida strain 890054

Toxin (Protein)


Gene name sanaT Uniprot ID A0A1Z3MNN1
Locus tag LJF99_RS23535 Protein ID WP_005321447.1
Coordinates 34959..35924 (-) Length 322 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID A0A807ZF76
Locus tag LJF99_RS23540 Protein ID WP_042468273.1
Coordinates 35914..36312 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF99_RS23505 (LJF99_23500) 30355..30960 - 606 WP_043816358.1 recombinase family protein -
LJF99_RS23510 (LJF99_23505) 31109..31810 - 702 WP_005321423.1 RNA ligase family protein -
LJF99_RS23515 (LJF99_23510) 31814..32347 - 534 WP_005321436.1 hypothetical protein -
LJF99_RS23520 (LJF99_23515) 32328..33737 - 1410 WP_005321439.1 DUF3696 domain-containing protein -
LJF99_RS23525 (LJF99_23520) 34168..34353 - 186 WP_005321442.1 hypothetical protein -
LJF99_RS23530 (LJF99_23525) 34483..34635 - 153 WP_005321445.1 Hok/Gef family protein -
LJF99_RS23535 (LJF99_23530) 34959..35924 - 966 WP_005321447.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
LJF99_RS23540 (LJF99_23535) 35914..36312 - 399 WP_042468273.1 DUF6088 family protein Antitoxin
LJF99_RS23545 (LJF99_23540) 37249..37695 + 447 WP_063968044.1 DNA repair protein RadC -
LJF99_RS23550 (LJF99_23545) 37735..38097 + 363 WP_063968043.1 hypothetical protein -
LJF99_RS23555 (LJF99_23550) 38443..39069 - 627 WP_149604794.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..74243 74243


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(43-302)

Antitoxin

Protein of unknown function DUF6088

(7-128)


Sequences

Toxin        


Download         Length: 322 a.a.        Molecular weight: 36512.59 Da        Isoelectric Point: 5.1489

>T220905 WP_005321447.1 NZ_CP085535:c35924-34959 [Aeromonas salmonicida subsp. salmonicida]
MQPKDSSIFADVSDYFGIDNPAIAEKDYYVVQLLKLLASHYCQHHTMVFAGGTALAKADVKLQRMSEDVDIKLSVNDSAK
DESRSAMKRHRKAIRDGLIEELNATGVFQVERAEVTCRDEHRYIEMPVRYPQAFSKAPCLRPFIKLELIETDLLAGHNPM
PICSLHNEAMQQEPEVPAFNTVPLISTQAEKVLSMLRRTASVKHDPERLDDESLVRHIYDTYRLQQSTTFDLAELAGLIA
EGMKMDRDRYGPQHPEFAADPIGVMRFGLDVIAGDPLYKDRYEAFVKPMVYGDALTWDEAFRVFEAVARQALDHIEQHEL
I

Download         Length: 966 bp

>T220905 NZ_CP117300:c2920340-2919762 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAGCGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCGCTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTTCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAAGCGGCGCACCCGGACAAGGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCATCTGGACAC
GCCGCTGCGCGATCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGATGCCTAG

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14761.36 Da        Isoelectric Point: 11.0142

>AT220905 WP_042468273.1 NZ_CP085535:c36312-35914 [Aeromonas salmonicida subsp. salmonicida]
MTIADRVEARIKRSKRDVFLREDFDDLGGYDQIGRALRQMCEKGLLLKVGYGVYAKARRNRINSRLMIASPGGPDAVLIA
TLDRLKVPYELKGLTAAYAAGKSTQVPAFMEVKPKKRFSRKLKIGSRVFNAA

Download         Length: 399 bp

>AT220905 NZ_CP117300:c2920982-2920428 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Z3MNN1

Antitoxin

Source ID Structure
AlphaFold DB A0A807ZF76

References