Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Txe-YefM |
| Location | 3725222..3725751 | Replicon | chromosome |
| Accession | NZ_CP085532 | ||
| Organism | Mycobacterium tuberculosis variant bovis BCG strain Moreau PL | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | G0TI95 |
| Locus tag | LJF87_RS17500 | Protein ID | WP_003417760.1 |
| Coordinates | 3725494..3725751 (+) | Length | 86 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | G0TI94 |
| Locus tag | LJF87_RS17495 | Protein ID | WP_003417757.1 |
| Coordinates | 3725222..3725497 (+) | Length | 92 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJF87_RS17460 (LJF87_17450) | 3721795..3722484 | - | 690 | WP_003917774.1 | BBE domain-containing protein | - |
| LJF87_RS17465 (LJF87_17455) | 3722671..3723042 | - | 372 | WP_003417739.1 | FAD-binding protein | - |
| LJF87_RS17470 | 3722940..3723158 | - | 219 | WP_157132559.1 | hypothetical protein | - |
| LJF87_RS17475 (LJF87_17460) | 3723185..3723445 | - | 261 | WP_003417741.1 | hypothetical protein | - |
| LJF87_RS17480 (LJF87_17465) | 3723560..3723949 | + | 390 | WP_010950876.1 | DUF732 domain-containing protein | - |
| LJF87_RS17485 (LJF87_17470) | 3723963..3724256 | - | 294 | WP_003417749.1 | DUF3017 domain-containing protein | - |
| LJF87_RS17490 (LJF87_17475) | 3724253..3725098 | - | 846 | WP_010950877.1 | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | - |
| LJF87_RS17495 (LJF87_17480) | 3725222..3725497 | + | 276 | WP_003417757.1 | type II toxin-antitoxin system antitoxin RelJ | Antitoxin |
| LJF87_RS17500 (LJF87_17485) | 3725494..3725751 | + | 258 | WP_003417760.1 | Txe/YoeB family addiction module toxin | Toxin |
| LJF87_RS17505 (LJF87_17490) | 3725793..3726983 | + | 1191 | WP_003900033.1 | NADH:flavin oxidoreductase | - |
| LJF87_RS17510 (LJF87_17495) | 3727100..3727468 | + | 369 | WP_003417765.1 | FHA domain-containing protein | - |
| LJF87_RS17515 (LJF87_17500) | 3727465..3728016 | - | 552 | WP_003417767.1 | pentapeptide repeat protein MfpA | - |
| LJF87_RS17520 (LJF87_17505) | 3728023..3728604 | - | 582 | WP_003417769.1 | ATP/GTP-binding protein | - |
| LJF87_RS17525 (LJF87_17510) | 3728585..3728953 | - | 369 | WP_003417772.1 | DUF742 domain-containing protein | - |
| LJF87_RS17530 (LJF87_17515) | 3728931..3729323 | - | 393 | WP_011799344.1 | serine protease inhibitor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10070.30 Da Isoelectric Point: 6.4693
>T220901 WP_003417760.1 NZ_CP085532:3725494-3725751 [Mycobacterium tuberculosis variant bovis BCG]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
Download Length: 258 bp
>T220901 NZ_CP117299:c4698608-4698240 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGCGCCTGA
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGCGCCTGA
Antitoxin
Download Length: 92 a.a. Molecular weight: 10194.35 Da Isoelectric Point: 4.6652
>AT220901 WP_003417757.1 NZ_CP085532:3725222-3725497 [Mycobacterium tuberculosis variant bovis BCG]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
Download Length: 276 bp
>AT220901 NZ_CP117299:c4698826-4698605 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGGCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGGCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|