Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-Phd |
| Location | 3114742..3115290 | Replicon | chromosome |
| Accession | NZ_CP085532 | ||
| Organism | Mycobacterium tuberculosis variant bovis BCG strain Moreau PL | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | G0TFG5 |
| Locus tag | LJF87_RS14800 | Protein ID | WP_003414602.1 |
| Coordinates | 3115027..3115290 (+) | Length | 88 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | O33347 |
| Locus tag | LJF87_RS14795 | Protein ID | WP_003414599.1 |
| Coordinates | 3114742..3115023 (+) | Length | 94 a.a. |
Genomic Context
Location: 3111952..3112200 (249 bp)
Type: Others
Protein ID: WP_003913411.1
Type: Others
Protein ID: WP_003913411.1
Location: 3112197..3112577 (381 bp)
Type: Others
Protein ID: WP_003414592.1
Type: Others
Protein ID: WP_003414592.1
Location: 3114742..3115023 (282 bp)
Type: Antitoxin
Protein ID: WP_003414599.1
Type: Antitoxin
Protein ID: WP_003414599.1
Location: 3115027..3115290 (264 bp)
Type: Toxin
Protein ID: WP_003414602.1
Type: Toxin
Protein ID: WP_003414602.1
Location: 3110365..3111222 (858 bp)
Type: Others
Protein ID: WP_003899513.1
Type: Others
Protein ID: WP_003899513.1
Location: 3111264..3111848 (585 bp)
Type: Others
Protein ID: WP_010950792.1
Type: Others
Protein ID: WP_010950792.1
Location: 3112659..3114470 (1812 bp)
Type: Others
Protein ID: WP_003414596.1
Type: Others
Protein ID: WP_003414596.1
Location: 3115663..3116517 (855 bp)
Type: Others
Protein ID: WP_003899516.1
Type: Others
Protein ID: WP_003899516.1
Location: 3116573..3117736 (1164 bp)
Type: Others
Protein ID: WP_003899517.1
Type: Others
Protein ID: WP_003899517.1
Location: 3117753..3118967 (1215 bp)
Type: Others
Protein ID: WP_011799297.1
Type: Others
Protein ID: WP_011799297.1
Location: 3118975..3120216 (1242 bp)
Type: Others
Protein ID: WP_003414613.1
Type: Others
Protein ID: WP_003414613.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJF87_RS14770 (LJF87_14765) | 3110365..3111222 | - | 858 | WP_003899513.1 | type I methionyl aminopeptidase | - |
| LJF87_RS14775 (LJF87_14770) | 3111264..3111848 | - | 585 | WP_010950792.1 | DUF1707 domain-containing protein | - |
| LJF87_RS14780 (LJF87_14775) | 3111952..3112200 | + | 249 | WP_003913411.1 | antitoxin VapB23 | - |
| LJF87_RS14785 (LJF87_14780) | 3112197..3112577 | + | 381 | WP_003414592.1 | type II toxin-antitoxin system VapC family toxin | - |
| LJF87_RS14790 (LJF87_14785) | 3112659..3114470 | - | 1812 | WP_003414596.1 | penicillin-binding protein | - |
| LJF87_RS14795 (LJF87_14790) | 3114742..3115023 | + | 282 | WP_003414599.1 | type II toxin-antitoxin system antitoxin RelF | Antitoxin |
| LJF87_RS14800 (LJF87_14795) | 3115027..3115290 | + | 264 | WP_003414602.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LJF87_RS14805 (LJF87_14800) | 3115663..3116517 | - | 855 | WP_003899516.1 | GNAT family N-acetyltransferase | - |
| LJF87_RS14810 (LJF87_14805) | 3116573..3117736 | - | 1164 | WP_003899517.1 | flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase | - |
| LJF87_RS14815 (LJF87_14810) | 3117753..3118967 | - | 1215 | WP_011799297.1 | zinc metalloprotease Rip | - |
| LJF87_RS14820 (LJF87_14815) | 3118975..3120216 | - | 1242 | WP_003414613.1 | 1-deoxy-D-xylulose-5-phosphate reductoisomerase | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| No matching records found | |||||||
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 88 a.a. Molecular weight: 10204.82 Da Isoelectric Point: 11.5078
>T220897 WP_003414602.1 NZ_CP085532:3115027-3115290 [Mycobacterium tuberculosis variant bovis BCG]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR
Download Length: 264 bp
>T220897 NZ_CP117299:c3012046-3011943 [Salmonella enterica subsp. enterica serovar Mbandaka]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 94 a.a. Molecular weight: 10183.40 Da Isoelectric Point: 4.3440
>AT220897 WP_003414599.1 NZ_CP085532:3114742-3115023 [Mycobacterium tuberculosis variant bovis BCG]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH
Download Length: 282 bp
>AT220897 NZ_CP117299:3011941-3012084 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAAGTTTTCCAGTTTG
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAAGTTTTCCAGTTTG
Structures
Toxin
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Source | ID | Structure |
|---|---|---|
| PDB | 3G5O |
Antitoxin
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Source | ID | Structure |
|---|---|---|
| PDB | 3G5O | |
| AlphaFold DB | A0A7U4BWP8 |