Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3114742..3115290 Replicon chromosome
Accession NZ_CP085532
Organism Mycobacterium tuberculosis variant bovis BCG strain Moreau PL

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag LJF87_RS14800 Protein ID WP_003414602.1
Coordinates 3115027..3115290 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag LJF87_RS14795 Protein ID WP_003414599.1
Coordinates 3114742..3115023 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF87_RS14770 (LJF87_14765) 3110365..3111222 - 858 WP_003899513.1 type I methionyl aminopeptidase -
LJF87_RS14775 (LJF87_14770) 3111264..3111848 - 585 WP_010950792.1 DUF1707 domain-containing protein -
LJF87_RS14780 (LJF87_14775) 3111952..3112200 + 249 WP_003913411.1 antitoxin VapB23 -
LJF87_RS14785 (LJF87_14780) 3112197..3112577 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
LJF87_RS14790 (LJF87_14785) 3112659..3114470 - 1812 WP_003414596.1 penicillin-binding protein -
LJF87_RS14795 (LJF87_14790) 3114742..3115023 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
LJF87_RS14800 (LJF87_14795) 3115027..3115290 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJF87_RS14805 (LJF87_14800) 3115663..3116517 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
LJF87_RS14810 (LJF87_14805) 3116573..3117736 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
LJF87_RS14815 (LJF87_14810) 3117753..3118967 - 1215 WP_011799297.1 zinc metalloprotease Rip -
LJF87_RS14820 (LJF87_14815) 3118975..3120216 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T220897 WP_003414602.1 NZ_CP085532:3115027-3115290 [Mycobacterium tuberculosis variant bovis BCG]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

>T220897 NZ_CP117299:c3012046-3011943 [Salmonella enterica subsp. enterica serovar Mbandaka]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT220897 WP_003414599.1 NZ_CP085532:3114742-3115023 [Mycobacterium tuberculosis variant bovis BCG]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp

>AT220897 NZ_CP117299:3011941-3012084 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAAGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References