Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PIN_Sll0205-like-Phd |
| Location | 3073825..3074429 | Replicon | chromosome |
| Accession | NZ_CP085532 | ||
| Organism | Mycobacterium tuberculosis variant bovis BCG strain Moreau PL | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | P71623 |
| Locus tag | LJF87_RS14600 | Protein ID | WP_003414492.1 |
| Coordinates | 3073825..3074217 (-) | Length | 131 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | A0A829CBY8 |
| Locus tag | LJF87_RS14605 | Protein ID | WP_003414495.1 |
| Coordinates | 3074214..3074429 (-) | Length | 72 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJF87_RS14570 (LJF87_14565) | 3068975..3069763 | - | 789 | WP_003917092.1 | CRISPR-associated endoribonuclease Cas6 | - |
| LJF87_RS14575 (LJF87_14570) | 3070097..3070642 | - | 546 | WP_003904931.1 | DUF1802 family protein | - |
| LJF87_RS14580 (LJF87_14575) | 3070914..3071798 | - | 885 | WP_003414409.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| LJF87_RS14585 (LJF87_14580) | 3071801..3072688 | - | 888 | WP_003414414.1 | type IV toxin-antitoxin system AbiEi family antitoxin | - |
| LJF87_RS14590 (LJF87_14585) | 3072993..3073538 | - | 546 | WP_003899500.1 | DUF1802 family protein | - |
| LJF87_RS14595 (LJF87_14590) | 3073535..3073804 | - | 270 | WP_003414489.1 | DUF2277 family protein | - |
| LJF87_RS14600 (LJF87_14595) | 3073825..3074217 | - | 393 | WP_003414492.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| LJF87_RS14605 (LJF87_14600) | 3074214..3074429 | - | 216 | WP_003414495.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| LJF87_RS14610 (LJF87_14605) | 3074476..3075225 | + | 750 | WP_003414497.1 | enoyl-CoA hydratase | - |
| LJF87_RS14615 (LJF87_14610) | 3075304..3076386 | - | 1083 | WP_011799293.1 | ABC transporter ATP-binding protein | - |
| LJF87_RS14620 (LJF87_14615) | 3076379..3077689 | - | 1311 | Protein_2885 | ABC transporter substrate-binding protein | - |
| LJF87_RS14625 (LJF87_14620) | 3077692..3078519 | - | 828 | WP_003414504.1 | carbohydrate ABC transporter permease | - |
| LJF87_RS14630 (LJF87_14625) | 3078516..3079427 | - | 912 | WP_003414505.1 | sugar ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 131 a.a. Molecular weight: 14610.74 Da Isoelectric Point: 6.7594
>T220896 WP_003414492.1 NZ_CP085532:c3074217-3073825 [Mycobacterium tuberculosis variant bovis BCG]
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW
Download Length: 393 bp
>T220896 NZ_CP117299:3004737-3005048 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGCATGTCATATCAAAAGAGCCTTTTGATGAAGCGGCAAGACGATATCCCAATGACTCGTTAGCCATAAAAGCCCTGTA
TCGCTTAGTCCGCGAAAGAGATTTCTCTTCTCCGGCAGAGCTACGAAAAGTCATACCGAGTCTCGATAACTTTAAGTACC
GTAACAAGTGGTGGGTACTGGATGTCGGAGGCAACAACCTGAGGGTGATCGCTTACATCAACTTTATAAACAAACGCTTT
TATGTGAAACACATCGCCACTCACGCTGAATATGACAAGCTGACCCGCTACTACAGGGAGAATAAAGAATGA
ATGCATGTCATATCAAAAGAGCCTTTTGATGAAGCGGCAAGACGATATCCCAATGACTCGTTAGCCATAAAAGCCCTGTA
TCGCTTAGTCCGCGAAAGAGATTTCTCTTCTCCGGCAGAGCTACGAAAAGTCATACCGAGTCTCGATAACTTTAAGTACC
GTAACAAGTGGTGGGTACTGGATGTCGGAGGCAACAACCTGAGGGTGATCGCTTACATCAACTTTATAAACAAACGCTTT
TATGTGAAACACATCGCCACTCACGCTGAATATGACAAGCTGACCCGCTACTACAGGGAGAATAAAGAATGA
Antitoxin
Download Length: 72 a.a. Molecular weight: 7511.55 Da Isoelectric Point: 4.9732
>AT220896 WP_003414495.1 NZ_CP085532:c3074429-3074214 [Mycobacterium tuberculosis variant bovis BCG]
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAVDDDELFTTGVSWNVS
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAVDDDELFTTGVSWNVS
Download Length: 216 bp
>AT220896 NZ_CP117299:3005045-3005464 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGATTGCCAACACCGCAAAAGCTATCGAAGCCACAAAGGCGCTGGTCGCCGCCGTTCCTTTCCTGGGTGGCAGCGCGTC
AGAGAAAGATTATCGTGATGCGCTAGCGCTGGTTGATTATCTTATCGAAAATGACGATGAAAACCCGCTGATTGACTTCC
TGGCAAGCAAAATTGCCGAGTACGAAGATAACAGCAAGCAGTTCGCCGAGTTCAACAAATCTGTTGCTGAAATGCCGGTT
GGTGTTGCCCTGCTGCGCACGCTAATTGACCAGTACAAACTCTCATACTCAGATCTTAAAGAAGAAATCGGTTCCAAATC
ACTGGTAAGTCAGATCCTGTCCGGACAGCGCTCGTTAACGATTACGCACATCAAAGCGCTTTCAGCACGATTTGGCGTGA
AACCTGAGTGGTTCTTATAA
ATGATTGCCAACACCGCAAAAGCTATCGAAGCCACAAAGGCGCTGGTCGCCGCCGTTCCTTTCCTGGGTGGCAGCGCGTC
AGAGAAAGATTATCGTGATGCGCTAGCGCTGGTTGATTATCTTATCGAAAATGACGATGAAAACCCGCTGATTGACTTCC
TGGCAAGCAAAATTGCCGAGTACGAAGATAACAGCAAGCAGTTCGCCGAGTTCAACAAATCTGTTGCTGAAATGCCGGTT
GGTGTTGCCCTGCTGCGCACGCTAATTGACCAGTACAAACTCTCATACTCAGATCTTAAAGAAGAAATCGGTTCCAAATC
ACTGGTAAGTCAGATCCTGTCCGGACAGCGCTCGTTAACGATTACGCACATCAAAGCGCTTTCAGCACGATTTGGCGTGA
AACCTGAGTGGTTCTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BWM8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829CBY8 |