Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 3046834..3047404 | Replicon | chromosome |
| Accession | NZ_CP085532 | ||
| Organism | Mycobacterium tuberculosis variant bovis BCG strain Moreau PL | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | P71650 |
| Locus tag | LJF87_RS14455 | Protein ID | WP_003414166.1 |
| Coordinates | 3046834..3047190 (-) | Length | 119 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | P0CL61 |
| Locus tag | LJF87_RS14460 | Protein ID | WP_003901465.1 |
| Coordinates | 3047174..3047404 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJF87_RS14435 (LJF87_14430) | 3042286..3043974 | - | 1689 | WP_003414155.1 | alpha/beta hydrolase family protein | - |
| LJF87_RS14440 (LJF87_14435) | 3043978..3044304 | - | 327 | WP_003414157.1 | hypothetical protein | - |
| LJF87_RS14445 (LJF87_14440) | 3044477..3045064 | + | 588 | WP_003914429.1 | DUF3558 family protein | - |
| LJF87_RS14450 (LJF87_14445) | 3045083..3046732 | + | 1650 | WP_003899485.1 | CocE/NonD family hydrolase | - |
| LJF87_RS14455 (LJF87_14450) | 3046834..3047190 | - | 357 | WP_003414166.1 | type II toxin-antitoxin system toxin endoribonuclease MazF9 | Toxin |
| LJF87_RS14460 (LJF87_14455) | 3047174..3047404 | - | 231 | WP_003901465.1 | type II toxin-antitoxin system antitoxin MazE9 | Antitoxin |
| LJF87_RS14465 (LJF87_14460) | 3047447..3048490 | - | 1044 | WP_003414172.1 | DUF2293 domain-containing protein | - |
| LJF87_RS14470 (LJF87_14465) | 3048489..3048956 | + | 468 | WP_003414177.1 | DUF1778 domain-containing protein | - |
| LJF87_RS14475 (LJF87_14470) | 3049132..3049386 | - | 255 | WP_003917684.1 | hypothetical protein | - |
| LJF87_RS14480 (LJF87_14475) | 3049534..3049938 | + | 405 | WP_003414181.1 | hypothetical protein | - |
| LJF87_RS14485 (LJF87_14480) | 3049935..3050126 | + | 192 | WP_003414184.1 | hypothetical protein | - |
| LJF87_RS14490 (LJF87_14485) | 3050343..3050603 | + | 261 | Protein_2859 | transposase | - |
| LJF87_RS14495 (LJF87_14490) | 3051713..3051970 | + | 258 | WP_003899489.1 | hypothetical protein | - |
| LJF87_RS14500 (LJF87_14495) | 3052075..3052386 | + | 312 | WP_010950777.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 12858.73 Da Isoelectric Point: 9.1962
>T220894 WP_003414166.1 NZ_CP085532:c3047190-3046834 [Mycobacterium tuberculosis variant bovis BCG]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS
Download Length: 357 bp
>T220894 NZ_CP117299:c1624001-1623783 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8231.01 Da Isoelectric Point: 4.1809
>AT220894 WP_003901465.1 NZ_CP085532:c3047404-3047174 [Mycobacterium tuberculosis variant bovis BCG]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR
Download Length: 231 bp
>AT220894 NZ_CP117299:c1624403-1624029 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|