Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3006838..3007517 Replicon chromosome
Accession NZ_CP085532
Organism Mycobacterium tuberculosis variant bovis BCG strain Moreau PL

Toxin (Protein)


Gene name vapC Uniprot ID P9WF90
Locus tag LJF87_RS14225 Protein ID WP_003414059.1
Coordinates 3006838..3007254 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TF64
Locus tag LJF87_RS14230 Protein ID WP_003414061.1
Coordinates 3007251..3007517 (-) Length 89 a.a.

Genomic Context

LJF87_RS14255LJF87_RS14270LJF87_RS14205LJF87_RS14210LJF87_RS14215LJF87_RS14220LJF87_RS14225LJF87_RS14230LJF87_RS14235LJF87_RS14240LJF87_RS14245LJF87_RS14250LJF87_RS14260LJF87_RS14265
Location: 3009723..3009797 (75 bp)
Type: Others
Protein ID: Protein_2812
Location: 3011304..3012041 (738 bp)
Type: Others
Protein ID: WP_011799288.1
Location: 3002890..3003792 (903 bp)
Type: Others
Protein ID: WP_003900564.1
Location: 3003861..3004613 (753 bp)
Type: Others
Protein ID: WP_003899465.1
Location: 3004857..3005132 (276 bp)
Type: Others
Protein ID: WP_003414055.1
Location: 3005129..3006751 (1623 bp)
Type: Others
Protein ID: WP_003414057.1
Location: 3006838..3007254 (417 bp)
Type: Toxin
Protein ID: WP_003414059.1
Location: 3007251..3007517 (267 bp)
Type: Antitoxin
Protein ID: WP_003414061.1
Location: 3007543..3007938 (396 bp)
Type: Others
Protein ID: WP_003414064.1
Location: 3007935..3008204 (270 bp)
Type: Others
Protein ID: WP_003414066.1
Location: 3008214..3009308 (1095 bp)
Type: Others
Protein ID: WP_003414068.1
Location: 3009305..3009724 (420 bp)
Type: Others
Protein ID: Protein_2811
Location: 3009798..3010277 (480 bp)
Type: Others
Protein ID: WP_003414073.1
Location: 3010348..3011148 (801 bp)
Type: Others
Protein ID: WP_003911953.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LJF87_RS14205 (LJF87_14195)3002890..3003792-903WP_003900564.14-hydroxy-tetrahydrodipicolinate synthase-
LJF87_RS14210 (LJF87_14200)3003861..3004613-753WP_003899465.1FAD-dependent thymidylate synthase-
LJF87_RS14215 (LJF87_14210)3004857..3005132-276WP_003414055.1type I restriction endonuclease subunit S-
LJF87_RS14220 (LJF87_14215)3005129..3006751-1623WP_003414057.1class I SAM-dependent DNA methyltransferase-
LJF87_RS14225 (LJF87_14220)3006838..3007254-417WP_003414059.1type II toxin-antitoxin system toxin ribonuclease C21Toxin
LJF87_RS14230 (LJF87_14225)3007251..3007517-267WP_003414061.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
LJF87_RS14235 (LJF87_14230)3007543..3007938-396WP_003414064.1type II toxin-antitoxin system VapC family toxin-
LJF87_RS14240 (LJF87_14235)3007935..3008204-270WP_003414066.1type II toxin-antitoxin system VapB family antitoxin-
LJF87_RS14245 (LJF87_14240)3008214..3009308-1095WP_003414068.1restriction endonuclease subunit S-
LJF87_RS14250 (LJF87_14245)3009305..3009724-420Protein_2811winged helix-turn-helix domain-containing protein-
LJF87_RS14255 (LJF87_14250)3009723..3009797+75Protein_2812hypothetical protein-
LJF87_RS14260 (LJF87_14255)3009798..3010277-480WP_003414073.1dihydrofolate reductase-
LJF87_RS14265 (LJF87_14260)3010348..3011148-801WP_003911953.1thymidylate synthase-
LJF87_RS14270 (LJF87_14265)3011304..3012041+738WP_011799288.1dienelactone hydrolase family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(16-56)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15773.00 Da        Isoelectric Point: 7.1294

>T220892 WP_003414059.1 NZ_CP085532:c3007254-3006838 [Mycobacterium tuberculosis variant bovis BCG]
MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEI
QEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA

Download         Length: 417 bp

>T220892 NZ_CP117299:c1438981-1438754 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGACCACCTGTTACTCACAAATCCCCAGCCAGCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCA
CGGCGTCACCGTGAAGATCTCCGAGGGGTGTTTGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGC
TTTATCAGGTGAAAAAGTCGATGAAGCATATTAAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9493.77 Da        Isoelectric Point: 7.2783

>AT220892 WP_003414061.1 NZ_CP085532:c3007517-3007251 [Mycobacterium tuberculosis variant bovis BCG]
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA

Download         Length: 267 bp

>AT220892 NZ_CP117299:1438764-1439175 [Salmonella enterica subsp. enterica serovar Mbandaka]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGTGGTCATGCAGGCTTTGCTGTTGATGTGG
CGGACGCTGACGCCGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAG
CTCAGGGCGAGCGAGTATGGGCGCGACATCCTGGCACTGCGCTCCCCTCTCCCCGGCCGGTGATGAGCAGCCGGCTGCCG
GGGCAGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB5SV2

Antitoxin

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Source
ID
Structure
AlphaFold DBG0TF64

References