Detailed information of TA system TA022089

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 373154..373659
• Replicon: chromosome
• Accession: NC_009483
• Organism: Geobacter uraniireducens Rf4

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A5GD15
• Locus tag: GURA_RS01600
• Protein ID: WP_011937255.1
• Coordinates: 373405..373659 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A5GD14
• Locus tag: GURA_RS01595
• Protein ID: WP_011937254.1
• Coordinates: 373154..373408 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GURA_RS01580	371853..372263	-	411	WP_041245655.1	putative toxin-antitoxin system toxin component, PIN family	-
GURA_RS01585	372260..372499	-	240	WP_011937252.1	AbrB family transcriptional regulator	-
GURA_RS01590	372624..373025	-	402	WP_011937253.1	hypothetical protein	-
GURA_RS01595	373154..373408	+	255	WP_011937254.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
GURA_RS01600	373405..373659	+	255	WP_011937255.1	Txe/YoeB family addiction module toxin	Toxin
GURA_RS01605	373808..375217	-	1410	WP_011937256.1	NADH-quinone oxidoreductase subunit N	-
GURA_RS01610	375468..376949	-	1482	WP_011937257.1	NADH-quinone oxidoreductase subunit M	-
GURA_RS01615	377033..377626	-	594	WP_011937258.1	hypothetical protein	-
GURA_RS24035	377742..377975	-	234	WP_157046103.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10081.57 Da
• Isoelectric Point: 7.8531

>T22089 WP_011937255.1 NC_009483:373405-373659 [Geobacter uraniireducens Rf4]
MNVTFTPTALDDLRYWLKTDKRQAERILALLEEIRRTPFDGTGKPEPLRFQLAGCWSRRIDREHRLVYQVEESEIVVIAC
RYHY

Nucleotide

• Length: 255 bp

>T22089 NC_009483:373405-373659 [Geobacter uraniireducens Rf4]
ATGAATGTTACGTTCACACCGACTGCTCTCGACGACCTGCGCTATTGGCTTAAGACCGATAAACGCCAGGCCGAACGGAT
CTTGGCGCTTCTTGAAGAAATTCGGCGAACCCCTTTTGATGGAACAGGAAAACCAGAACCCCTCCGTTTTCAGCTTGCCG
GTTGCTGGTCCCGCAGGATTGACAGGGAACATCGCCTTGTATACCAAGTGGAAGAAAGTGAGATTGTCGTTATCGCCTGT
CGCTATCACTACTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9435.72 Da
• Isoelectric Point: 4.8254

>AT22089 WP_011937254.1 NC_009483:373154-373408 [Geobacter uraniireducens Rf4]
MHAITYSEARHALKDVMDEACSNHEPILITRRKGENVVLLSLEDYESIMESEYLLSSPANAARLMQSLEEARSGKRTPMD
TLGL

Nucleotide

• Length: 255 bp

>AT22089 NC_009483:373154-373408 [Geobacter uraniireducens Rf4]
ATGCATGCAATCACATACAGCGAAGCACGTCATGCCCTTAAGGACGTCATGGACGAAGCTTGCAGCAACCACGAACCGAT
CCTGATCACGCGTCGTAAGGGAGAGAATGTAGTCCTGTTAAGCCTTGAAGACTACGAGTCCATTATGGAAAGCGAATATC
TGCTTTCCAGTCCTGCTAATGCAGCACGGCTAATGCAATCTCTTGAAGAGGCACGGTCCGGCAAGCGAACCCCCATGGAT
ACTCTTGGGCTATGA

Structures

Toxin

• AlphaFold DB: A5GD15

Antitoxin

• AlphaFold DB: A5GD14