Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2816277..2816908 Replicon chromosome
Accession NZ_CP085532
Organism Mycobacterium tuberculosis variant bovis BCG strain Moreau PL

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ28
Locus tag LJF87_RS13200 Protein ID WP_003413174.1
Coordinates 2816531..2816908 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag LJF87_RS13195 Protein ID WP_003413167.1
Coordinates 2816277..2816534 (+) Length 86 a.a.

Genomic Context

LJF87_RS13160LJF87_RS13165LJF87_RS13170LJF87_RS13175LJF87_RS13180LJF87_RS13185LJF87_RS13190LJF87_RS13195LJF87_RS13200LJF87_RS13205LJF87_RS13210LJF87_RS13215LJF87_RS13220LJF87_RS13225LJF87_RS13230LJF87_RS13235
Location: 2811535..2811849 (315 bp)
Type: Others
Protein ID: WP_009937839.1
Location: 2812145..2813356 (1212 bp)
Type: Others
Protein ID: WP_003900845.1
Location: 2813483..2814142 (660 bp)
Type: Others
Protein ID: WP_003900846.1
Location: 2814139..2814798 (660 bp)
Type: Others
Protein ID: WP_003900847.1
Location: 2814795..2815457 (663 bp)
Type: Others
Protein ID: WP_003900848.1
Location: 2815454..2815732 (279 bp)
Type: Others
Protein ID: WP_003901422.1
Location: 2815825..2816238 (414 bp)
Type: Others
Protein ID: WP_003413164.1
Location: 2816277..2816534 (258 bp)
Type: Antitoxin
Protein ID: WP_003413167.1
Location: 2816531..2816908 (378 bp)
Type: Toxin
Protein ID: WP_003413174.1
Location: 2816924..2817298 (375 bp)
Type: Others
Protein ID: WP_003413177.1
Location: 2817398..2817793 (396 bp)
Type: Others
Protein ID: WP_003413180.1
Location: 2817790..2818035 (246 bp)
Type: Others
Protein ID: WP_003413183.1
Location: 2818446..2818865 (420 bp)
Type: Others
Protein ID: WP_003413190.1
Location: 2818877..2819685 (809 bp)
Type: Others
Protein ID: Protein_2610
Location: 2819682..2820935 (1254 bp)
Type: Others
Protein ID: WP_274485783.1
Location: 2820928..2821440 (513 bp)
Type: Others
Protein ID: WP_003413197.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LJF87_RS13160 (LJF87_13150)2811535..2811849+315WP_009937839.1hypothetical protein-
LJF87_RS13165 (LJF87_13155)2812145..2813356+1212WP_003900845.1alpha/beta hydrolase family protein-
LJF87_RS13170 (LJF87_13160)2813483..2814142+660WP_003900846.1LppA family lipoprotein-
LJF87_RS13175 (LJF87_13165)2814139..2814798+660WP_003900847.1LppA family lipoprotein-
LJF87_RS13180 (LJF87_13170)2814795..2815457+663WP_003900848.1LppA family lipoprotein-
LJF87_RS13185 (LJF87_13175)2815454..2815732+279WP_003901422.1type II toxin-antitoxin system VapB family antitoxin-
LJF87_RS13190 (LJF87_13180)2815825..2816238+414WP_003413164.1PIN domain nuclease-
LJF87_RS13195 (LJF87_13185)2816277..2816534+258WP_003413167.1CopG family transcriptional regulatorAntitoxin
LJF87_RS13200 (LJF87_13190)2816531..2816908+378WP_003413174.1type II toxin-antitoxin system VapC family toxinToxin
LJF87_RS13205 (LJF87_13195)2816924..2817298-375WP_003413177.1hypothetical protein-
LJF87_RS13210 (LJF87_13200)2817398..2817793-396WP_003413180.1type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20-
LJF87_RS13215 (LJF87_13205)2817790..2818035-246WP_003413183.1type II toxin-antitoxin system antitoxin VapB20-
LJF87_RS13220 (LJF87_13210)2818446..2818865-420WP_003413190.1A24 family peptidase-
LJF87_RS13225 (LJF87_13215)2818877..2819685-809Protein_2610shikimate dehydrogenase-
LJF87_RS13230 (LJF87_13220)2819682..2820935-1254WP_274485783.1endolytic transglycosylase MltG-
LJF87_RS13235 (LJF87_13225)2820928..2821440-513WP_003413197.1Holliday junction resolvase RuvX-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13728.72 Da        Isoelectric Point: 4.4687

>T220889 WP_003413174.1 NZ_CP085532:2816531-2816908 [Mycobacterium tuberculosis variant bovis BCG]
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY

Download         Length: 378 bp

>T220889 NZ_CP117299:879574-879882 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGGTTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT220889 WP_003413167.1 NZ_CP085532:2816277-2816534 [Mycobacterium tuberculosis variant bovis BCG]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT220889 NZ_CP117299:879332-879571 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGTCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCTGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGCGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBG0TQ28

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A829C9W5

References