Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2755098..2755750 Replicon chromosome
Accession NZ_CP085532
Organism Mycobacterium tuberculosis variant bovis BCG strain Moreau PL

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag LJF87_RS12905 Protein ID WP_003412752.1
Coordinates 2755325..2755750 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag LJF87_RS12900 Protein ID WP_003412749.1
Coordinates 2755098..2755319 (+) Length 74 a.a.

Genomic Context

LJF87_RS12890LJF87_RS12895LJF87_RS12900LJF87_RS12905LJF87_RS12885LJF87_RS12910LJF87_RS12915LJF87_RS12920LJF87_RS12925LJF87_RS12930
Location: 2753680..2754303 (624 bp)
Type: Others
Protein ID: WP_003900858.1
Location: 2754293..2755045 (753 bp)
Type: Others
Protein ID: WP_003901416.1
Location: 2755098..2755319 (222 bp)
Type: Antitoxin
Protein ID: WP_003412749.1
Location: 2755325..2755750 (426 bp)
Type: Toxin
Protein ID: WP_003412752.1
Location: 2753338..2753544 (207 bp)
Type: Others
Protein ID: WP_003899347.1
Location: 2755773..2756954 (1182 bp)
Type: Others
Protein ID: WP_010950729.1
Location: 2756951..2757997 (1047 bp)
Type: Others
Protein ID: WP_010950730.1
Location: 2758008..2759111 (1104 bp)
Type: Others
Protein ID: WP_003412761.1
Location: 2759370..2760191 (822 bp)
Type: Others
Protein ID: WP_003412766.1
Location: 2760188..2760745 (558 bp)
Type: Others
Protein ID: WP_003412768.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LJF87_RS12885 (LJF87_12875)2753338..2753544-207WP_003899347.1hypothetical protein-
LJF87_RS12890 (LJF87_12880)2753680..2754303+624WP_003900858.1TIGR00725 family protein-
LJF87_RS12895 (LJF87_12885)2754293..2755045+753WP_003901416.1hypothetical protein-
LJF87_RS12900 (LJF87_12890)2755098..2755319+222WP_003412749.1antitoxinAntitoxin
LJF87_RS12905 (LJF87_12895)2755325..2755750+426WP_003412752.1type II toxin-antitoxin system VapC family toxinToxin
LJF87_RS12910 (LJF87_12900)2755773..2756954-1182WP_010950729.1dihydrolipoamide acetyltransferase family protein-
LJF87_RS12915 (LJF87_12905)2756951..2757997-1047WP_010950730.13-methyl-2-oxobutanoate dehydrogenase subunit beta-
LJF87_RS12920 (LJF87_12910)2758008..2759111-1104WP_003412761.1pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha-
LJF87_RS12925 (LJF87_12915)2759370..2760191-822WP_003412766.1citrate (pro-3S)-lyase subunit beta-
LJF87_RS12930 (LJF87_12920)2760188..2760745-558WP_003412768.1MaoC family dehydratase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T220886 WP_003412752.1 NZ_CP085532:2755325-2755750 [Mycobacterium tuberculosis variant bovis BCG]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T220886 NZ_CP117299:351800-352111 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGTTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGATCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCCTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT220886 WP_003412749.1 NZ_CP085532:2755098-2755319 [Mycobacterium tuberculosis variant bovis BCG]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT220886 NZ_CP117299:352112-352402 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBG0TPX1

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7U4BW03

References