Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2365628..2366157 Replicon chromosome
Accession NZ_CP085532
Organism Mycobacterium tuberculosis variant bovis BCG strain Moreau PL

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag LJF87_RS11060 Protein ID WP_003411124.1
Coordinates 2365628..2365945 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag LJF87_RS11065 Protein ID WP_003411127.1
Coordinates 2365942..2366157 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF87_RS11030 (LJF87_11030) 2360765..2361841 + 1077 WP_003411110.1 hypothetical protein -
LJF87_RS11035 (LJF87_11035) 2361838..2362119 + 282 WP_019283661.1 DUF5703 family protein -
LJF87_RS11040 (LJF87_11040) 2362155..2363228 + 1074 WP_011799246.1 quinone-dependent dihydroorotate dehydrogenase -
LJF87_RS11045 (LJF87_11045) 2363233..2363763 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
LJF87_RS11050 (LJF87_11050) 2363811..2365157 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
LJF87_RS11060 (LJF87_11060) 2365628..2365945 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJF87_RS11065 (LJF87_11065) 2365942..2366157 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
LJF87_RS11070 (LJF87_11070) 2366412..2367470 + 1059 WP_003411129.1 phosphoribosyltransferase family protein -
LJF87_RS11075 (LJF87_11075) 2367600..2367956 - 357 WP_003411130.1 hypothetical protein -
LJF87_RS11080 (LJF87_11080) 2368051..2368833 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
LJF87_RS11085 (LJF87_11085) 2369101..2369391 - 291 WP_003900476.1 YggT family protein -
LJF87_RS11090 (LJF87_11090) 2369553..2370209 - 657 WP_003411133.1 cell division protein SepF -
LJF87_RS11095 (LJF87_11095) 2370275..2371051 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T220885 WP_003411124.1 NZ_CP085532:c2365945-2365628 [Mycobacterium tuberculosis variant bovis BCG]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T220885 NZ_CP117299:c350567-350256 [Salmonella enterica subsp. enterica serovar Mbandaka]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT220885 WP_003411127.1 NZ_CP085532:c2366157-2365942 [Mycobacterium tuberculosis variant bovis BCG]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT220885 NZ_CP117299:c350259-349813 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCAGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References