220884

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2328964..2329659 Replicon chromosome
Accession NZ_CP085532
Organism Mycobacterium tuberculosis variant bovis BCG strain Moreau PL

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag LJF87_RS10855 Protein ID WP_003410811.1
Coordinates 2328964..2329398 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag LJF87_RS10860 Protein ID WP_003410814.1
Coordinates 2329405..2329659 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF87_RS10845 (LJF87_10845) 2325118..2328159 + 3042 WP_010950658.1 DEAD/DEAH box helicase -
LJF87_RS10850 (LJF87_10850) 2328152..2328985 + 834 WP_003899172.1 SWIM zinc finger family protein -
LJF87_RS10855 (LJF87_10855) 2328964..2329398 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
LJF87_RS10860 (LJF87_10860) 2329405..2329659 - 255 WP_003410814.1 antitoxin Antitoxin
LJF87_RS10865 (LJF87_10865) 2329675..2329932 - 258 WP_003410816.1 hypothetical protein -
LJF87_RS10870 (LJF87_10870) 2330879..2331175 + 297 WP_003410820.1 PE family protein -
LJF87_RS10875 (LJF87_10875) 2331231..2331962 + 732 WP_003900467.1 PPE family protein -
LJF87_RS10880 (LJF87_10880) 2332502..2333248 - 747 WP_003901330.1 proteasome subunit alpha -
LJF87_RS10885 (LJF87_10885) 2333245..2334120 - 876 WP_003411023.1 proteasome subunit beta -
LJF87_RS10890 (LJF87_10890) 2334117..2334311 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T220884 WP_003410811.1 NZ_CP085532:c2329398-2328964 [Mycobacterium tuberculosis variant bovis BCG]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T220884 NZ_CP117298:3772726-3773136 [Mycobacterium tuberculosis variant bovis]
GTGATCTATATGGACACCTCGGCCCTGACTAAGCTGCTCATCTCCGAGCCCGAGACGACCGAACTGCGGACATGGCTGAC
CGCGCAAAGCGGCCAGGGCGAGGACGCGGCGACAAGCACCCTTGGCCGGGTCGAGTTGATGAGAGTCGTTGCCCGATACG
GACAACCAGGCCAAACTGAGCGTGCGCGTTACCTACTCGACGGGCTCGACATCCTCCCGCTCACCGAACCGGTGATCGGT
CTAGCTGAAACGATCGGACCGGCCACCCTACGTTCTCTCGACGCGATTCACCTCGCGGCCGCAGCCCAGATCAAGCGGGA
ACTGACAGCCTTCGTCACCTACGACCACCGATTGTTGAGCGGATGCCGTGAGGTCGGCTTCGTCACCGCCTCACCCGGCG
CAGTCCGGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT220884 WP_003410814.1 NZ_CP085532:c2329659-2329405 [Mycobacterium tuberculosis variant bovis BCG]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT220884 NZ_CP117298:3772451-3772729 [Mycobacterium tuberculosis variant bovis]
GTGGAGGCAATCGGAATCCGAGAACTAAGACAGCACGCATCGCGATACCTCGCCCGGGTTGAAGCCGGCGAGGAACTTGG
CGTCACCAACAAAGGAAGACTTGTGGCCCGACTCATCCCGGTGCAGGCCGCGGAGCGTTCTCGCGAAGCCCTGATTGAAT
CAGGTGTCCTGATTCCGGCTCGTCGTCCACAAAACCTTCTCGACGTCACCGCCGAACCGGCGCGCGGCCGCAAGCGCACC
CTGTCCGATGTTCTCAACGAAATGCGCGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References