Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2197351..2198039 Replicon chromosome
Accession NZ_CP085532
Organism Mycobacterium tuberculosis variant bovis BCG strain Moreau PL

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag LJF87_RS10250 Protein ID WP_003409958.1
Coordinates 2197351..2197770 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag LJF87_RS10255 Protein ID WP_003409968.1
Coordinates 2197779..2198039 (-) Length 87 a.a.

Genomic Context

LJF87_RS10220LJF87_RS10225LJF87_RS10230LJF87_RS10260LJF87_RS10270LJF87_RS10280LJF87_RS10235LJF87_RS10240LJF87_RS10245LJF87_RS10250LJF87_RS10255LJF87_RS10265LJF87_RS10275
Location: 2192357..2192662 (306 bp)
Type: Others
Protein ID: Protein_2019
Location: 2192658..2192738 (81 bp)
Type: Others
Protein ID: Protein_2020
Location: 2192846..2193694 (849 bp)
Type: Others
Protein ID: WP_003409942.1
Location: 2198182..2199858 (1677 bp)
Type: Others
Protein ID: WP_010950639.1
Location: 2200614..2200844 (231 bp)
Type: Others
Protein ID: WP_003409980.1
Location: 2201949..2202548 (600 bp)
Type: Others
Protein ID: WP_003409989.1
Location: 2193657..2195102 (1446 bp)
Type: Others
Protein ID: WP_003409946.1
Location: 2195281..2195967 (687 bp)
Type: Others
Protein ID: WP_003409954.1
Location: 2196158..2197126 (969 bp)
Type: Others
Protein ID: WP_003409956.1
Location: 2197351..2197770 (420 bp)
Type: Toxin
Protein ID: WP_003409958.1
Location: 2197779..2198039 (261 bp)
Type: Antitoxin
Protein ID: WP_003409968.1
Location: 2199846..2200499 (654 bp)
Type: Others
Protein ID: WP_003409976.1
Location: 2200929..2201840 (912 bp)
Type: Others
Protein ID: WP_003409986.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LJF87_RS10220 (LJF87_10215)2192357..2192662+306Protein_2019ABC transporter permease-
LJF87_RS10225 (LJF87_10220)2192658..2192738+81Protein_2020hypothetical protein-
LJF87_RS10230 (LJF87_10225)2192846..2193694+849WP_003409942.1class I SAM-dependent methyltransferase-
LJF87_RS10235 (LJF87_10230)2193657..2195102-1446WP_003409946.1APC family permease-
LJF87_RS10240 (LJF87_10235)2195281..2195967-687WP_003409954.1immunoprotective protein Mpt64-
LJF87_RS10245 (LJF87_10240)2196158..2197126-969WP_003409956.1class 1b ribonucleoside-diphosphate reductase subunit beta-
LJF87_RS10250 (LJF87_10245)2197351..2197770-420WP_003409958.1type II toxin-antitoxin system VapC family toxinToxin
LJF87_RS10255 (LJF87_10250)2197779..2198039-261WP_003409968.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
LJF87_RS10260 (LJF87_10255)2198182..2199858+1677WP_010950639.1PecA family PE domain-processing aspartic protease-
LJF87_RS10265 (LJF87_10260)2199846..2200499-654WP_003409976.1cutinase Cfp21-
LJF87_RS10270 (LJF87_10265)2200614..2200844+231WP_003409980.1DUF167 domain-containing protein-
LJF87_RS10275 (LJF87_10270)2200929..2201840-912WP_003409986.1ArgP/LysG family DNA-binding transcriptional regulator-
LJF87_RS10280 (LJF87_10275)2201949..2202548+600WP_003409989.1L-lysine exporter-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T220879 WP_003409958.1 NZ_CP085532:c2197770-2197351 [Mycobacterium tuberculosis variant bovis BCG]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T220879 NZ_CP117298:3133551-3133994 [Mycobacterium tuberculosis variant bovis]
ATGCTGTGCGTTGATGTCAACGTGCTCGTTTACGCGCATCGGGCAGACCTACGGGAGCACGCGGACTATCGGGGTTTGCT
TGAGCGGCTGGCCAACGATGACGAGCCGCTGGGTCTACCAGATAGCGTGCTCGCCGGCTTCATCCGGGTGGTTACCAACC
GCCGCGTCTTCACCGAGCCGACGAGCCCACAGGACGCATGGCAGGCAGTCGACGCCCTACTCGCGGCACCCGCAGCCATG
CGACTTCGGCCTGGCGAGCGCCACTGGATGGCCTTTCGGCAGTTAGCGTCCGATGTTGATGCGAACGGCAACGACATTGC
GGACGCGCACCTGGCCGCCTACGCGCTAGAGAACAACGCAACCTGGTTGAGCGCCGACCGCGGCTTTGCCCGTTTCCGTC
GACTGCGCTGGCGTCATCCGTTGGACGGTCAGACCCATCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT220879 WP_003409968.1 NZ_CP085532:c2198039-2197779 [Mycobacterium tuberculosis variant bovis BCG]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT220879 NZ_CP117298:3133307-3133564 [Mycobacterium tuberculosis variant bovis]
GTGCGCACGACGATCCGTATCGATGACGAGCTGTACCGCGAGGTGAAAGCAAAGGCCGCTCGTTCCGGGCGTACCGTGGC
CGCGGTTCTTGAAGATGCGGTGCGGCGTGGTCTCAACCCGCCTAAGCCGCAGGCCGCCGGCCGTTATCGAGTCCAGCCGT
CGGGTAAGGGCGGCCTGCGGCCCGGTGTCGATCTATCGTCCAACGCCGCACTTGCCGAAGCGATGAACGACGGCGTGTCG
GTCGATGCTGTGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A829C4H9

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A829C483

References