Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1572284..1572939 Replicon chromosome
Accession NZ_CP085532
Organism Mycobacterium tuberculosis variant bovis BCG strain Moreau PL

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4FAR1
Locus tag LJF87_RS07445 Protein ID WP_003407268.1
Coordinates 1572284..1572685 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag LJF87_RS07450 Protein ID WP_003407272.1
Coordinates 1572682..1572939 (-) Length 86 a.a.

Genomic Context

LJF87_RS07435LJF87_RS07465LJF87_RS07470LJF87_RS07430LJF87_RS07440LJF87_RS07445LJF87_RS07450LJF87_RS07455LJF87_RS07460
Location: 1569591..1570625 (1035 bp)
Type: Others
Protein ID: WP_003407264.1
Location: 1574967..1575704 (738 bp)
Type: Others
Protein ID: WP_031647000.1
Location: 1575785..1577752 (1968 bp)
Type: Others
Protein ID: WP_003407285.1
Location: 1568128..1569513 (1386 bp)
Type: Others
Protein ID: WP_003407260.1
Location: 1570671..1572029 (1359 bp)
Type: Others
Protein ID: WP_010950541.1
Location: 1572284..1572685 (402 bp)
Type: Toxin
Protein ID: WP_003407268.1
Location: 1572682..1572939 (258 bp)
Type: Antitoxin
Protein ID: WP_003407272.1
Location: 1573022..1573981 (960 bp)
Type: Others
Protein ID: WP_011799179.1
Location: 1574006..1574968 (963 bp)
Type: Others
Protein ID: WP_003407279.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LJF87_RS07430 (LJF87_07395)1568128..1569513-1386WP_003407260.1cytochrome P450-
LJF87_RS07435 (LJF87_07400)1569591..1570625+1035WP_003407264.1AraC family transcriptional regulator-
LJF87_RS07440 (LJF87_07405)1570671..1572029-1359WP_010950541.1PE family protein-
LJF87_RS07445 (LJF87_07410)1572284..1572685-402WP_003407268.1type II toxin-antitoxin system VapC family toxinToxin
LJF87_RS07450 (LJF87_07415)1572682..1572939-258WP_003407272.1CopG family transcriptional regulatorAntitoxin
LJF87_RS07455 (LJF87_07420)1573022..1573981-960WP_011799179.1alpha/beta hydrolase-
LJF87_RS07460 (LJF87_07425)1574006..1574968-963WP_003407279.1alpha/beta hydrolase-
LJF87_RS07465 (LJF87_07430)1574967..1575704+738WP_031647000.1lysoplasmalogenase-
LJF87_RS07470 (LJF87_07435)1575785..1577752+1968WP_003407285.1primosomal protein N'-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14894.39 Da        Isoelectric Point: 11.6897

>T220871 WP_003407268.1 NZ_CP085532:c1572685-1572284 [Mycobacterium tuberculosis variant bovis BCG]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQGLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

>T220871 NZ_CP117298:c2830827-2830432 [Mycobacterium tuberculosis variant bovis]
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT220871 WP_003407272.1 NZ_CP085532:c1572939-1572682 [Mycobacterium tuberculosis variant bovis BCG]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp

>AT220871 NZ_CP117298:c2831069-2830824 [Mycobacterium tuberculosis variant bovis]
ATGCTAGTGGCGTATATTTGCCATGTGAAAAGGCTGCAGATCTACATCGACGAAGACGTTGACCGAGCGCTTGCTGTTGA
AGCGCGACGGCGGCGGACGTCGAAGGCGGCGCTGATCCGGGAGTACGTCGCTGAGCACCTCCGGCAGCCGGGCCCAGATC
CGGTCGATGCCTTCGTCGGATCGTTCGTGGGGGAAGCCGACTTGTCCGCGTCCGTCGACGACGTGGTTTACGGAAAGCAC
GAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7U4FAR1

Antitoxin

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Source
ID
Structure
AlphaFold DBG0TIK2

References