Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 1538290..1539340 Replicon chromosome
Accession NZ_CP085532
Organism Mycobacterium tuberculosis variant bovis BCG strain Moreau PL

Toxin (Protein)


Gene name phRel Uniprot ID G0TIH2
Locus tag LJF87_RS07295 Protein ID WP_003407164.1
Coordinates 1538290..1539111 (+) Length 274 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID A0A7U4BTV8
Locus tag LJF87_RS07300 Protein ID WP_003407167.1
Coordinates 1539104..1539340 (+) Length 79 a.a.

Genomic Context

LJF87_RS07295LJF87_RS07300LJF87_RS07310LJF87_RS07315LJF87_RS07275LJF87_RS07280LJF87_RS07285LJF87_RS07290LJF87_RS07305
Location: 1538290..1539111 (822 bp)
Type: Toxin
Protein ID: WP_003407164.1
Location: 1539104..1539340 (237 bp)
Type: Antitoxin
Protein ID: WP_003407167.1
Location: 1540920..1541705 (786 bp)
Type: Others
Protein ID: WP_003407180.1
Location: 1541901..1543371 (1471 bp)
Type: Others
Protein ID: Protein_1440
Location: 1533848..1534510 (663 bp)
Type: Others
Protein ID: WP_010950531.1
Location: 1534507..1535292 (786 bp)
Type: Others
Protein ID: WP_003407157.1
Location: 1535583..1537544 (1962 bp)
Type: Others
Protein ID: WP_010950533.1
Location: 1537683..1538069 (387 bp)
Type: Others
Protein ID: WP_003407162.1
Location: 1539412..1540617 (1206 bp)
Type: Others
Protein ID: WP_003918234.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LJF87_RS07275 (LJF87_07240)1533848..1534510-663WP_010950531.1hypothetical protein-
LJF87_RS07280 (LJF87_07245)1534507..1535292-786WP_003407157.1membrane protein-
LJF87_RS07285 (LJF87_07250)1535583..1537544-1962WP_010950533.1sigma-F factor regulator-
LJF87_RS07290 (LJF87_07255)1537683..1538069-387WP_003407162.1anti-sigma-F factor antagonist RsfA-
LJF87_RS07295 (LJF87_07260)1538290..1539111+822WP_003407164.1GTP pyrophosphokinase family proteinToxin
LJF87_RS07300 (LJF87_07265)1539104..1539340+237WP_003407167.1hypothetical proteinAntitoxin
LJF87_RS07305 (LJF87_07270)1539412..1540617-1206WP_003918234.1serine hydrolase domain-containing protein-
LJF87_RS07310 (LJF87_07275)1540920..1541705+786WP_003407180.1lipoprotein LprF-
LJF87_RS07315 (LJF87_07280)1541901..1543371+1471Protein_1440cytochrome b5 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 274 a.a.        Molecular weight: 30100.10 Da        Isoelectric Point: 5.8187

>T220870 WP_003407164.1 NZ_CP085532:1538290-1539111 [Mycobacterium tuberculosis variant bovis BCG]
VVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKS
QDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNKATVLATTKFRLERAINEAESAGGGG

Download         Length: 822 bp

>T220870 NZ_CP117298:2829565-2829942 [Mycobacterium tuberculosis variant bovis]
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8830.90 Da        Isoelectric Point: 7.3178

>AT220870 WP_003407167.1 NZ_CP085532:1539104-1539340 [Mycobacterium tuberculosis variant bovis BCG]
VGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR

Download         Length: 237 bp

>AT220870 NZ_CP117298:2829311-2829568 [Mycobacterium tuberculosis variant bovis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBG0TIH2

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7U4BTV8

References