Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1233914..1234545 Replicon chromosome
Accession NZ_CP085532
Organism Mycobacterium tuberculosis variant bovis BCG strain Moreau PL

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4F9D0
Locus tag LJF87_RS05900 Protein ID WP_003405820.1
Coordinates 1233914..1234225 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag LJF87_RS05905 Protein ID WP_003405836.1
Coordinates 1234225..1234545 (-) Length 107 a.a.

Genomic Context

LJF87_RS05890LJF87_RS05910LJF87_RS05880LJF87_RS05885LJF87_RS05895LJF87_RS05900LJF87_RS05905LJF87_RS05915LJF87_RS05920LJF87_RS05925LJF87_RS05930
Location: 1231995..1232639 (645 bp)
Type: Others
Protein ID: WP_174813088.1
Location: 1234555..1236091 (1537 bp)
Type: Others
Protein ID: Protein_1164
Location: 1229396..1230820 (1425 bp)
Type: Others
Protein ID: WP_003405805.1
Location: 1230851..1231939 (1089 bp)
Type: Others
Protein ID: WP_003898726.1
Location: 1232646..1233802 (1157 bp)
Type: Others
Protein ID: Protein_1161
Location: 1233914..1234225 (312 bp)
Type: Toxin
Protein ID: WP_003405820.1
Location: 1234225..1234545 (321 bp)
Type: Antitoxin
Protein ID: WP_003405836.1
Location: 1236098..1237210 (1113 bp)
Type: Others
Protein ID: WP_003405840.1
Location: 1237220..1237477 (258 bp)
Type: Others
Protein ID: WP_003405844.1
Location: 1237467..1238714 (1248 bp)
Type: Others
Protein ID: WP_003405846.1
Location: 1238711..1239349 (639 bp)
Type: Others
Protein ID: WP_011799158.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LJF87_RS05880 (LJF87_05845)1229396..1230820-1425WP_003405805.1class II fumarate hydratase-
LJF87_RS05885 (LJF87_05850)1230851..1231939-1089WP_003898726.1class II fructose-bisphosphatase-
LJF87_RS05890 (LJF87_05855)1231995..1232639+645WP_174813088.1DUF4245 domain-containing protein-
LJF87_RS05895 (LJF87_05860)1232646..1233802-1157Protein_1161AI-2E family transporter-
LJF87_RS05900 (LJF87_05865)1233914..1234225-312WP_003405820.1type II toxin-antitoxin system toxin endoribonuclease MazF3Toxin
LJF87_RS05905 (LJF87_05870)1234225..1234545-321WP_003405836.1type II toxin-antitoxin system antitoxin MazE3Antitoxin
LJF87_RS05910 (LJF87_05875)1234555..1236091+1537Protein_1164carboxylesterase/lipase family protein-
LJF87_RS05915 (LJF87_05880)1236098..1237210-1113WP_003405840.13 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase-
LJF87_RS05920 (LJF87_05885)1237220..1237477-258WP_003405844.1exodeoxyribonuclease VII small subunit-
LJF87_RS05925 (LJF87_05890)1237467..1238714-1248WP_003405846.1exodeoxyribonuclease VII large subunit-
LJF87_RS05930 (LJF87_05895)1238711..1239349-639WP_011799158.1lipid droplet-associated protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11061.82 Da        Isoelectric Point: 4.9371

>T220866 WP_003405820.1 NZ_CP085532:c1234225-1233914 [Mycobacterium tuberculosis variant bovis BCG]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

>T220866 NZ_CP117298:c2376250-2375933 [Mycobacterium tuberculosis variant bovis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT220866 WP_003405836.1 NZ_CP085532:c1234545-1234225 [Mycobacterium tuberculosis variant bovis BCG]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp

>AT220866 NZ_CP117298:c2376462-2376247 [Mycobacterium tuberculosis variant bovis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7U4F9D0

Antitoxin

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Source
ID
Structure
AlphaFold DBG0TGZ7

References