Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1016995..1017614 Replicon chromosome
Accession NZ_CP085532
Organism Mycobacterium tuberculosis variant bovis BCG strain Moreau PL

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag LJF87_RS04825 Protein ID WP_003404726.1
Coordinates 1017180..1017614 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID G0TFQ5
Locus tag LJF87_RS04820 Protein ID WP_003404724.1
Coordinates 1016995..1017174 (+) Length 60 a.a.

Genomic Context

LJF87_RS04805LJF87_RS04810LJF87_RS04815LJF87_RS04820LJF87_RS04825LJF87_RS04830LJF87_RS04835LJF87_RS04840LJF87_RS04845LJF87_RS04850
Location: 1012468..1014048 (1581 bp)
Type: Others
Protein ID: WP_011799139.1
Location: 1014045..1016438 (2394 bp)
Type: Others
Protein ID: WP_003898639.1
Location: 1016711..1016869 (159 bp)
Type: Others
Protein ID: WP_003404720.1
Location: 1016995..1017174 (180 bp)
Type: Antitoxin
Protein ID: WP_003404724.1
Location: 1017180..1017614 (435 bp)
Type: Toxin
Protein ID: WP_003404726.1
Location: 1017712..1018485 (774 bp)
Type: Others
Protein ID: WP_003404735.1
Location: 1018550..1018999 (450 bp)
Type: Others
Protein ID: WP_003404738.1
Location: 1019134..1019364 (231 bp)
Type: Others
Protein ID: WP_003898642.1
Location: 1019531..1021039 (1509 bp)
Type: Others
Protein ID: WP_003404742.1
Location: 1021041..1022279 (1239 bp)
Type: Others
Protein ID: WP_003404744.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LJF87_RS04805 (LJF87_04780)1012468..1014048+1581WP_011799139.1serine hydrolase-
LJF87_RS04810 (LJF87_04785)1014045..1016438+2394WP_003898639.1cation-translocating P-type ATPase-
LJF87_RS04815 (LJF87_04790)1016711..1016869+159WP_003404720.1hypothetical protein-
LJF87_RS04820 (LJF87_04795)1016995..1017174+180WP_003404724.1antitoxinAntitoxin
LJF87_RS04825 (LJF87_04800)1017180..1017614+435WP_003404726.1SRPBCC family proteinToxin
LJF87_RS04830 (LJF87_04805)1017712..1018485+774WP_003404735.1VOC family protein-
LJF87_RS04835 (LJF87_04810)1018550..1018999+450WP_003404738.1hypothetical protein-
LJF87_RS04840 (LJF87_04815)1019134..1019364-231WP_003898642.1hypothetical protein-
LJF87_RS04845 (LJF87_04820)1019531..1021039-1509WP_003404742.1carotenoid oxygenase family protein-
LJF87_RS04850 (LJF87_04825)1021041..1022279-1239WP_003404744.1acetyl-CoA acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T220863 WP_003404726.1 NZ_CP085532:1017180-1017614 [Mycobacterium tuberculosis variant bovis BCG]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

>T220863 NZ_CP117298:2230413-2230811 [Mycobacterium tuberculosis variant bovis]
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6394.06 Da        Isoelectric Point: 4.3059

>AT220863 WP_003404724.1 NZ_CP085532:1016995-1017174 [Mycobacterium tuberculosis variant bovis BCG]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLQDAASNVVGMSDQQS

Download         Length: 180 bp

>AT220863 NZ_CP117298:2230185-2230412 [Mycobacterium tuberculosis variant bovis]
GTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACTCGATTCCAAGCGAAG
TGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTT
TCGACTTCAGCGACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBG0TFQ5

References