Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 843211..843920 Replicon chromosome
Accession NZ_CP085532
Organism Mycobacterium tuberculosis variant bovis BCG strain Moreau PL

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4F979
Locus tag LJF87_RS03985 Protein ID WP_003903160.1
Coordinates 843492..843920 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TEX4
Locus tag LJF87_RS03980 Protein ID WP_003403834.1
Coordinates 843211..843468 (+) Length 86 a.a.

Genomic Context

LJF87_RS03975LJF87_RS03980LJF87_RS03985LJF87_RS03995LJF87_RS03990LJF87_RS04000LJF87_RS04005LJF87_RS04010
Location: 840439..843120 (2682 bp)
Type: Others
Protein ID: WP_011799126.1
Location: 843211..843468 (258 bp)
Type: Antitoxin
Protein ID: WP_003403834.1
Location: 843492..843920 (429 bp)
Type: Toxin
Protein ID: WP_003903160.1
Location: 844297..844542 (246 bp)
Type: Others
Protein ID: WP_003403841.1
Location: 844001..844138 (138 bp)
Type: Others
Protein ID: WP_003403839.1
Location: 844611..845495 (885 bp)
Type: Others
Protein ID: WP_011799127.1
Location: 845506..846678 (1173 bp)
Type: Others
Protein ID: WP_010950438.1
Location: 846685..848217 (1533 bp)
Type: Others
Protein ID: WP_003403847.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LJF87_RS03975 (LJF87_03950)840439..843120+2682WP_011799126.1PE family protein-
LJF87_RS03980 (LJF87_03955)843211..843468+258WP_003403834.1ribbon-helix-helix protein, CopG familyAntitoxin
LJF87_RS03985 (LJF87_03960)843492..843920+429WP_003903160.1type II toxin-antitoxin system VapC family toxinToxin
LJF87_RS03990 (LJF87_03965)844001..844138-138WP_003403839.1hypothetical protein-
LJF87_RS03995 (LJF87_03975)844297..844542+246WP_003403841.1hypothetical protein-
LJF87_RS04000 (LJF87_03980)844611..845495-885WP_011799127.13-hydroxyisobutyrate dehydrogenase-
LJF87_RS04005 (LJF87_03985)845506..846678-1173WP_010950438.1acyl-CoA dehydrogenase family protein-
LJF87_RS04010 (LJF87_03990)846685..848217-1533WP_003403847.1CoA-acylating methylmalonate-semialdehyde dehydrogenase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-133)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15799.21 Da        Isoelectric Point: 7.5536

>T220862 WP_003903160.1 NZ_CP085532:843492-843920 [Mycobacterium tuberculosis variant bovis BCG]
MFLLDANVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLATNRRIFEIPSPRAEAFAFVEAVTAQPHHL
PTNPGPRHLVLLRKLCDEADASGDLIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL

Download         Length: 429 bp

>T220862 NZ_CP117298:c2206789-2206445 [Mycobacterium tuberculosis variant bovis]
GTGGTGATTAGTCGTGCCGAGATCTACTGGGCTGACCTCGGGCCGCCATCAGGCAGTCAGCCGGCGAAGCGCCGCCCGGT
GCTCGTAATCCAGTCAGATCCGTACAACGCAAGTCGCCTTGCCACTGTGATCGCAGCGGTGATCACGTCCAATACGGCGC
TGGCGGCAATGCCCGGCAACGTGTTCTTGCCCGCGACCACAACGCGACTGCCACGTGACTCGGTCGTCAACGTCACGGCG
ATTGTCACGCTCAACAAGACTGACCTCACCGACCGAGTTGGGGAGGTGCCAGCGAGCTTGATGCACGAGGTTGACCGAGG
ACTTCGTCGCGTACTGGACCTTTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9114.28 Da        Isoelectric Point: 10.6530

>AT220862 WP_003403834.1 NZ_CP085532:843211-843468 [Mycobacterium tuberculosis variant bovis BCG]
MRTTVSISDEILAAAKRRARERGQSLGAVIEDALRREFAAAHVGGARPTVPVFDGGTGPRRGIDLTSNRALSEVLDEGLE
LNSRK

Download         Length: 258 bp

>AT220862 NZ_CP117298:c2207031-2206783 [Mycobacterium tuberculosis variant bovis]
ATGAAGACAGCTATTTCTCTGCCGGATGAGACGTTCGATCGGGTATCGCGGCGTGCGAGTGAGCTCGGCATGAGTCGGTC
CGAGTTCTTCACGAAGGCTGCGCAGCGCTACCTGCACGAGCTGGACGCCCAATTGCTCACGGGCCAGATCGACAGGGCTC
TAGAGAGCATCCATGGCACCGACGAAGCGGAGGCCCTCGCCGTGGCCAACGCATACCGCGTGCTAGAAACCATGGACGAT
GAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7U4F979

Antitoxin

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Source
ID
Structure
AlphaFold DBG0TEX4

References