Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 712149..712774 Replicon chromosome
Accession NZ_CP085532
Organism Mycobacterium tuberculosis variant bovis BCG strain Moreau PL

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag LJF87_RS03260 Protein ID WP_003403218.1
Coordinates 712373..712774 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag LJF87_RS03255 Protein ID WP_003403213.1
Coordinates 712149..712376 (+) Length 76 a.a.

Genomic Context

LJF87_RS03235LJF87_RS03245LJF87_RS03250LJF87_RS03255LJF87_RS03260LJF87_RS03265LJF87_RS03270LJF87_RS03275LJF87_RS03280LJF87_RS03285LJF87_RS03230LJF87_RS03240
Location: 707691..708296 (606 bp)
Type: Others
Protein ID: WP_003898526.1
Location: 710966..711715 (750 bp)
Type: Others
Protein ID: WP_003898528.1
Location: 711712..711954 (243 bp)
Type: Others
Protein ID: WP_003403210.1
Location: 712149..712376 (228 bp)
Type: Antitoxin
Protein ID: WP_003403213.1
Location: 712373..712774 (402 bp)
Type: Toxin
Protein ID: WP_003403218.1
Location: 712903..712986 (84 bp)
Type: Others
Protein ID: Protein_647
Location: 713005..714087 (1083 bp)
Type: Others
Protein ID: WP_031652152.1
Location: 714084..715175 (1092 bp)
Type: Others
Protein ID: WP_003403225.1
Location: 715570..716727 (1158 bp)
Type: Others
Protein ID: WP_003903091.1
Location: 716738..717685 (948 bp)
Type: Others
Protein ID: WP_003403232.1
Location: 707328..707549 (222 bp)
Type: Others
Protein ID: WP_003898525.1
Location: 708315..710882 (2568 bp)
Type: Others
Protein ID: WP_003900188.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LJF87_RS03230 (LJF87_03205)707328..707549-222WP_003898525.1DUF4926 domain-containing protein-
LJF87_RS03235 (LJF87_03210)707691..708296+606WP_003898526.1hypothetical protein-
LJF87_RS03240 (LJF87_03215)708315..710882-2568WP_003900188.1SEC-C metal-binding domain-containing protein-
LJF87_RS03245 (LJF87_03220)710966..711715+750WP_003898528.1hypothetical protein-
LJF87_RS03250 (LJF87_03225)711712..711954+243WP_003403210.1hypothetical protein-
LJF87_RS03255 (LJF87_03230)712149..712376+228WP_003403213.1antitoxin VapB29Antitoxin
LJF87_RS03260 (LJF87_03235)712373..712774+402WP_003403218.1type II toxin-antitoxin system ribonuclease VapC29Toxin
LJF87_RS03265 (LJF87_03240)712903..712986+84Protein_647galactose-1-phosphate uridylyltransferase-
LJF87_RS03270 (LJF87_03245)713005..714087+1083WP_031652152.1galactose-1-phosphate uridylyltransferase-
LJF87_RS03275 (LJF87_03250)714084..715175+1092WP_003403225.1galactokinase-
LJF87_RS03280 (LJF87_03255)715570..716727+1158WP_003903091.1hypothetical protein-
LJF87_RS03285 (LJF87_03260)716738..717685+948WP_003403232.1DUF732 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T220855 WP_003403218.1 NZ_CP085532:712373-712774 [Mycobacterium tuberculosis variant bovis BCG]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T220855 NZ_CP117298:c1925693-1925304 [Mycobacterium tuberculosis variant bovis]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT220855 WP_003403213.1 NZ_CP085532:712149-712376 [Mycobacterium tuberculosis variant bovis BCG]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT220855 NZ_CP117298:c1925917-1925690 [Mycobacterium tuberculosis variant bovis]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBG0TQA0

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7U4BSC9

References