Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/AbrB(antitoxin)
Location 698521..699167 Replicon chromosome
Accession NZ_CP085532
Organism Mycobacterium tuberculosis variant bovis BCG strain Moreau PL

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ88
Locus tag LJF87_RS03155 Protein ID WP_003403137.1
Coordinates 698521..698934 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ89
Locus tag LJF87_RS03160 Protein ID WP_003403139.1
Coordinates 698931..699167 (-) Length 79 a.a.

Genomic Context

LJF87_RS03135LJF87_RS03180LJF87_RS03185LJF87_RS03190LJF87_RS03195LJF87_RS03140LJF87_RS03145LJF87_RS03150LJF87_RS03155LJF87_RS03160LJF87_RS03165LJF87_RS03170LJF87_RS03175
Location: 694604..696154 (1551 bp)
Type: Others
Protein ID: WP_003403119.1
Location: 701223..701534 (312 bp)
Type: Others
Protein ID: WP_003403164.1
Location: 701606..702556 (951 bp)
Type: Others
Protein ID: WP_003907436.1
Location: 702797..703381 (585 bp)
Type: Others
Protein ID: WP_003403171.1
Location: 703383..704093 (711 bp)
Type: Others
Protein ID: Protein_633
Location: 696206..696598 (393 bp)
Type: Others
Protein ID: WP_003403122.1
Location: 696595..696852 (258 bp)
Type: Others
Protein ID: WP_003403125.1
Location: 697035..698270 (1236 bp)
Type: Others
Protein ID: WP_003403128.1
Location: 698521..698934 (414 bp)
Type: Toxin
Protein ID: WP_003403137.1
Location: 698931..699167 (237 bp)
Type: Antitoxin
Protein ID: WP_003403139.1
Location: 699271..699777 (507 bp)
Type: Others
Protein ID: WP_003900973.1
Location: 699891..700421 (531 bp)
Type: Others
Protein ID: WP_003917320.1
Location: 700405..701100 (696 bp)
Type: Others
Protein ID: WP_197044064.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LJF87_RS03135 (LJF87_03105)694604..696154+1551WP_003403119.1MlaD family protein-
LJF87_RS03140 (LJF87_03110)696206..696598-393WP_003403122.1type II toxin-antitoxin system toxin ribonuclease C4-
LJF87_RS03145 (LJF87_03115)696595..696852-258WP_003403125.1type II toxin-antitoxin system antitoxin VapB4-
LJF87_RS03150 (LJF87_03120)697035..698270-1236WP_003403128.1ATP-binding protein-
LJF87_RS03155 (LJF87_03125)698521..698934-414WP_003403137.1type II toxin-antitoxin system VapC family toxinToxin
LJF87_RS03160 (LJF87_03130)698931..699167-237WP_003403139.1type II toxin-antitoxin system antitoxin VapB27Antitoxin
LJF87_RS03165 (LJF87_03135)699271..699777-507WP_003900973.1two component system sensor kinase HK1-
LJF87_RS03170 (LJF87_03140)699891..700421-531WP_003917320.1two component system sensor kinase HK2-
LJF87_RS03175 (LJF87_03145)700405..701100-696WP_197044064.1two-component system response regulator TcrA-
LJF87_RS03180 (LJF87_03150)701223..701534+312WP_003403164.1hypothetical protein-
LJF87_RS03185 (LJF87_03155)701606..702556+951WP_003907436.1DUF1259 domain-containing protein-
LJF87_RS03190 (LJF87_03160)702797..703381+585WP_003403171.1IS607-like element IS1536 family transposase-
LJF87_RS03195 (LJF87_03165)703383..704093+711Protein_633IS607 family element RNA-guided endonuclease TnpB-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-126)

Antitoxin

SpoVT-AbrB domain

(3-43)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14786.14 Da        Isoelectric Point: 8.1405

>T220853 WP_003403137.1 NZ_CP085532:c698934-698521 [Mycobacterium tuberculosis variant bovis BCG]
VKPPLAVDTSVAIPLLVRTHTAHAAVVAWWAHREAALCGHALAETYSVLTRLPRDLRLAPMDAARLLTERFAAPLLLSSR
TTEHLPRVLAQFEITGGAVYDALVALAAAEHRAELATRDARAKDTYEKIGVHVVVAA

Download         Length: 414 bp

>T220853 NZ_CP117298:1688104-1688421 [Mycobacterium tuberculosis variant bovis]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8212.41 Da        Isoelectric Point: 5.0351

>AT220853 WP_003403139.1 NZ_CP085532:c699167-698931 [Mycobacterium tuberculosis variant bovis BCG]
MKAVVDAAGRIVVPKPLREALGLQPGSTVEISRYGAGLHLIPTGRTARLEEENGVLVATGETTIDDEVVFGLIDSGRK

Download         Length: 237 bp

>AT220853 NZ_CP117298:1687805-1688107 [Mycobacterium tuberculosis variant bovis]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBG0TQ88

Antitoxin

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Source
ID
Structure
AlphaFold DBG0TQ89

References