Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 445367..446378 Replicon chromosome
Accession NZ_CP085532
Organism Mycobacterium tuberculosis variant bovis BCG strain Moreau PL

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag LJF87_RS01945 Protein ID WP_003401859.1
Coordinates 445367..445960 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag LJF87_RS01950 Protein ID WP_003401860.1
Coordinates 445989..446378 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF87_RS01925 (LJF87_01900) 441016..442398 + 1383 WP_003898415.1 magnesium transporter -
LJF87_RS01930 (LJF87_01905) 442410..443444 - 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
LJF87_RS01935 (LJF87_01910) 443540..444223 + 684 WP_010950388.1 VTT domain-containing protein -
LJF87_RS01940 (LJF87_01915) 444212..445342 - 1131 WP_003401858.1 glycoside hydrolase family 76 protein -
LJF87_RS01945 (LJF87_01920) 445367..445960 - 594 WP_003401859.1 zeta toxin family protein Toxin
LJF87_RS01950 (LJF87_01925) 445989..446378 - 390 WP_003401860.1 hypothetical protein Antitoxin
LJF87_RS01955 (LJF87_01930) 446459..447670 - 1212 WP_003401861.1 VWA domain-containing protein -
LJF87_RS01960 (LJF87_01935) 447676..448278 - 603 WP_003898417.1 SRPBCC family protein -
LJF87_RS01965 (LJF87_01940) 448292..449188 - 897 WP_003401863.1 MoxR family ATPase -
LJF87_RS01970 (LJF87_01945) 449185..449778 - 594 WP_003401864.1 NTP transferase domain-containing protein -
LJF87_RS01975 (LJF87_01950) 449775..450530 - 756 WP_003401865.1 XdhC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T220850 WP_003401859.1 NZ_CP085532:c445960-445367 [Mycobacterium tuberculosis variant bovis BCG]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

>T220850 NZ_CP117298:c1390632-1390339 [Mycobacterium tuberculosis variant bovis]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT220850 WP_003401860.1 NZ_CP085532:c446378-445989 [Mycobacterium tuberculosis variant bovis BCG]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp

>AT220850 NZ_CP117298:c1390898-1390629 [Mycobacterium tuberculosis variant bovis]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References