Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 954460..955052 Replicon chromosome
Accession NZ_CP085530
Organism Vogesella sp. XCS3

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LCH97_RS04490 Protein ID WP_227303601.1
Coordinates 954798..955052 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LCH97_RS04485 Protein ID WP_227303600.1
Coordinates 954460..954801 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCH97_RS04440 (LCH97_04440) 949994..951214 + 1221 WP_227303590.1 phage major capsid protein -
LCH97_RS04445 (LCH97_04445) 951271..951468 + 198 WP_227303591.1 hypothetical protein -
LCH97_RS04450 (LCH97_04450) 951471..951815 + 345 WP_227303592.1 head-tail connector protein -
LCH97_RS04455 (LCH97_04455) 951882..952139 + 258 WP_255619276.1 phage head closure protein -
LCH97_RS04460 (LCH97_04460) 952136..952675 + 540 WP_227303594.1 HK97 gp10 family phage protein -
LCH97_RS04465 (LCH97_04465) 952675..953019 + 345 WP_227303595.1 DUF3168 domain-containing protein -
LCH97_RS04470 (LCH97_04470) 953091..953735 + 645 WP_227303597.1 phage tail protein -
LCH97_RS04475 (LCH97_04475) 953778..954092 + 315 WP_227303599.1 phage tail assembly chaperone -
LCH97_RS04480 (LCH97_04480) 954155..954406 + 252 WP_227305262.1 DUF1799 domain-containing protein -
LCH97_RS04485 (LCH97_04485) 954460..954801 - 342 WP_227303600.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LCH97_RS04490 (LCH97_04490) 954798..955052 - 255 WP_227303601.1 type II toxin-antitoxin system HicA family toxin Toxin
LCH97_RS04495 (LCH97_04495) 955240..955653 + 414 WP_227303602.1 hypothetical protein -
LCH97_RS04500 (LCH97_04500) 955710..958469 + 2760 WP_227303603.1 phage tail length tape measure family protein -
LCH97_RS04505 (LCH97_04505) 958502..958852 + 351 WP_227303605.1 hypothetical protein -
LCH97_RS04510 (LCH97_04510) 958895..959371 + 477 WP_227303607.1 DUF1833 family protein -
LCH97_RS04515 (LCH97_04515) 959371..959769 + 399 WP_227303609.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9552.93 Da        Isoelectric Point: 10.2672

>T220844 WP_227303601.1 NZ_CP085530:c955052-954798 [Vogesella sp. XCS3]
MKRKHQATLEQIYSRPVSGTIRWKDIEALFVELGAGIEEREGSRVGVTLFSQVRVFHRPHPSPETDKAAVASIRKWLEEN
GVKP

Download         Length: 255 bp

>T220844 NZ_CP117298:843091-843519 [Mycobacterium tuberculosis variant bovis]
ATGTTCCTTCTCGACGCCAACGTGCTGCTGGCTGCACACCGCGGTGACCACCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACCGCTCGCGGCTGACGACCCCTTCACAGTGCCGAACCTGGTATGGGCGTCGTTCCTCCGGCTGGCAACGAATC
GACGCATCTTCGAGATTCCGTCACCGCGAGCAGAGGCATTCGCATTCGTCGAAGCCGTCACCGCCCAGCCCCATCACCTT
CCGACGAACCCCGGTCCCAGACACCTCATGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGCGGCCATAGCAGTGGGGCATCACTGCGCCGTGGTGAGCCTGGACAGGGATTTCGCCCGGTTTGCCT
CGGTGCGCCACATTCGCCCGCCGCTCTAG

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12174.78 Da        Isoelectric Point: 4.6363

>AT220844 WP_227303600.1 NZ_CP085530:c954801-954460 [Vogesella sp. XCS3]
MNNIMIINGQKATVSYDPEIEMFRGEFLGLTGGADFYAADVAGLKAEGEVSLRVYLDMCQEKGIEPYRSYSGKFNVRIAS
ALHAVAAMSAAAQGKSLNEWVADAIEDHAGHMA

Download         Length: 342 bp

>AT220844 NZ_CP117298:842810-843067 [Mycobacterium tuberculosis variant bovis]
ATGCGCACCACGGTGTCAATCTCCGATGAAATACTCGCTGCCGCCAAACGCCGGGCCCGCGAGCGTGGTCAATCGCTGGG
CGCTGTGATCGAGGACGCCCTTCGGCGGGAGTTCGCCGCCGCCCACGTCGGCGGCGCCCGCCCGACCGTCCCGGTTTTCG
ACGGCGGCACCGGTCCGCGGCGAGGCATCGACCTGACCTCGAATAGAGCGTTGTCCGAAGTGCTCGACGAGGGCCTGGAA
CTGAACTCCCGGAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References