Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 414448..415115 Replicon plasmid pSymB
Accession NZ_CP085528
Organism Sinorhizobium meliloti strain L6-AK89

Toxin (Protein)


Gene name vapC Uniprot ID A0A8B3N559
Locus tag LJD24_RS26765 Protein ID WP_017266625.1
Coordinates 414448..414891 (-) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q92WE1
Locus tag LJD24_RS26770 Protein ID WP_010975287.1
Coordinates 414888..415115 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJD24_RS26745 (LJD24_26745) 409905..412097 + 2193 WP_013849983.1 hydantoinase B/oxoprolinase family protein -
LJD24_RS26750 (LJD24_26750) 412101..412598 + 498 WP_017270158.1 acetone carboxylase subunit gamma -
LJD24_RS26755 (LJD24_26755) 412595..413425 + 831 WP_013849981.1 SDR family oxidoreductase -
LJD24_RS26760 (LJD24_26760) 413494..414432 + 939 WP_013849980.1 choline ABC transporter substrate-binding protein -
LJD24_RS26765 (LJD24_26765) 414448..414891 - 444 WP_017266625.1 PIN domain-containing protein Toxin
LJD24_RS26770 (LJD24_26770) 414888..415115 - 228 WP_010975287.1 hypothetical protein Antitoxin
LJD24_RS26775 (LJD24_26775) 415299..415772 - 474 WP_015008545.1 DUF2269 family protein -
LJD24_RS26780 (LJD24_26780) 415772..417061 - 1290 WP_028006038.1 SDR family oxidoreductase -
LJD24_RS26785 (LJD24_26785) 417431..418723 + 1293 WP_013849976.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
LJD24_RS26790 (LJD24_26790) 418841..419722 + 882 WP_003525869.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - htpB 1..1645902 1645902


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-131)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 15638.95 Da        Isoelectric Point: 6.6378

>T220841 WP_017266625.1 NZ_CP085528:c414891-414448 [Sinorhizobium meliloti]
VTFLLDVNVLIALIDPSHIGHDDAHEWFASMGQTAWATCPITENGVIRIVGNPEYPNSPGSPLPVMEIVAKLRSLPGHVF
WPDDVSLVGSSDIIPSKILTSGQVTDTYLLALAKARGGKLATFDRKLSAAAVTKGNSALHLIATNRS

Download         Length: 444 bp

>T220841 NZ_CP117298:c756440-756132 [Mycobacterium tuberculosis variant bovis]
ATGCGGCGCGGTGAATTGTGGTTTGCCGCCACACCTGGTGGTGACAGACCAGTACTTGTCCTTACCAGAGATCCGGTGGC
AGACCGCATCGGCGCGGTCGTTGTGGTGGCCCTAACCCGCACCCGCCGAGGCCTGGTGTCGGAATTGGAGCTCACGGCCG
TCGAAAACCGTGTTCCGAGCGACTGCGTCGTCAACTTCGACAACATTCATACGTTGCCACGCACCGCATTCCGACGCCGC
ATCACCCGGCTGTCCCCGGCCCGCCTGCACGAAGCCTGTCAAACACTCCGGGCGAGCACGGGGTGTTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8174.39 Da        Isoelectric Point: 9.1096

>AT220841 WP_010975287.1 NZ_CP085528:c415115-414888 [Sinorhizobium meliloti]
MRTTLAIDDDVLIAAKAMATQQQRSVGEVISELARRSLRRPRSGGERNGIPLLSPRPDAPPVTLEIVNALRDELA

Download         Length: 228 bp

>AT220841 NZ_CP117298:c756672-756427 [Mycobacterium tuberculosis variant bovis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B3N559

Antitoxin

Source ID Structure
AlphaFold DB Q92WE1

References