Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/RHH(antitoxin) |
Location | 74901..75435 | Replicon | plasmid pSymB |
Accession | NZ_CP085528 | ||
Organism | Sinorhizobium meliloti strain L6-AK89 |
Toxin (Protein)
Gene name | parE | Uniprot ID | - |
Locus tag | LJD24_RS25115 | Protein ID | WP_017268214.1 |
Coordinates | 75139..75435 (+) | Length | 99 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | H0FXK0 |
Locus tag | LJD24_RS25110 | Protein ID | WP_003527850.1 |
Coordinates | 74901..75149 (+) | Length | 83 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LJD24_RS25085 (LJD24_25085) | 70355..71440 | + | 1086 | WP_028005417.1 | ABC transporter substrate-binding protein | - |
LJD24_RS25090 (LJD24_25090) | 71437..72480 | + | 1044 | WP_033043685.1 | iron ABC transporter permease | - |
LJD24_RS25095 (LJD24_25095) | 72477..73277 | + | 801 | WP_028005415.1 | ABC transporter ATP-binding protein | - |
LJD24_RS25100 (LJD24_25100) | 73281..74075 | + | 795 | WP_028005414.1 | methyltransferase domain-containing protein | - |
LJD24_RS25105 (LJD24_25105) | 74159..74284 | - | 126 | Protein_63 | IS481 family transposase | - |
LJD24_RS25110 (LJD24_25110) | 74901..75149 | + | 249 | WP_003527850.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
LJD24_RS25115 (LJD24_25115) | 75139..75435 | + | 297 | WP_017268214.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
LJD24_RS25120 (LJD24_25120) | 75514..75774 | - | 261 | Protein_66 | helix-turn-helix domain-containing protein | - |
LJD24_RS25125 (LJD24_25125) | 76348..76746 | + | 399 | WP_010974988.1 | hypothetical protein | - |
LJD24_RS25130 (LJD24_25130) | 76913..77098 | + | 186 | WP_015243548.1 | hypothetical protein | - |
LJD24_RS25135 (LJD24_25135) | 77102..77548 | - | 447 | WP_014527651.1 | DNA-binding protein | - |
LJD24_RS25140 (LJD24_25140) | 77837..78046 | + | 210 | WP_003527838.1 | dodecin family protein | - |
LJD24_RS25145 (LJD24_25145) | 78582..79961 | + | 1380 | WP_027991363.1 | sodium:alanine symporter family protein | - |
LJD24_RS25150 (LJD24_25150) | 79998..80144 | + | 147 | Protein_72 | transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Mobilizable plasmid | - | htpB | 1..1645902 | 1645902 | |
- | flank | IS/Tn | - | - | 74159..74350 | 191 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11490.20 Da Isoelectric Point: 10.7543
>T220840 WP_017268214.1 NZ_CP085528:75139-75435 [Sinorhizobium meliloti]
MATERPFRLAPAAKADLRKIWRYKARRWSLEQAETYQDQLYTAFEGLAAGTKKGRNVDVRPGYLKYPAGSHIVYFRDRGD
RIDIIRILHGRMDAQRHL
MATERPFRLAPAAKADLRKIWRYKARRWSLEQAETYQDQLYTAFEGLAAGTKKGRNVDVRPGYLKYPAGSHIVYFRDRGD
RIDIIRILHGRMDAQRHL
Download Length: 297 bp
>T220840 NZ_CP117298:c754814-754431 [Mycobacterium tuberculosis variant bovis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG
Antitoxin
Download Length: 83 a.a. Molecular weight: 8888.73 Da Isoelectric Point: 4.2176
>AT220840 WP_003527850.1 NZ_CP085528:74901-75149 [Sinorhizobium meliloti]
MAARSTSISLGDHFAGFIDSQVQTGRYGSASDVVRAGLRLLEEHEAKVRALEAALIEGEESGEPEPFDNEAFKAEMRAEY
GD
MAARSTSISLGDHFAGFIDSQVQTGRYGSASDVVRAGLRLLEEHEAKVRALEAALIEGEESGEPEPFDNEAFKAEMRAEY
GD
Download Length: 249 bp
>AT220840 NZ_CP117298:c755064-754909 [Mycobacterium tuberculosis variant bovis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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