Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 74901..75435 Replicon plasmid pSymB
Accession NZ_CP085528
Organism Sinorhizobium meliloti strain L6-AK89

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag LJD24_RS25115 Protein ID WP_017268214.1
Coordinates 75139..75435 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID H0FXK0
Locus tag LJD24_RS25110 Protein ID WP_003527850.1
Coordinates 74901..75149 (+) Length 83 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJD24_RS25085 (LJD24_25085) 70355..71440 + 1086 WP_028005417.1 ABC transporter substrate-binding protein -
LJD24_RS25090 (LJD24_25090) 71437..72480 + 1044 WP_033043685.1 iron ABC transporter permease -
LJD24_RS25095 (LJD24_25095) 72477..73277 + 801 WP_028005415.1 ABC transporter ATP-binding protein -
LJD24_RS25100 (LJD24_25100) 73281..74075 + 795 WP_028005414.1 methyltransferase domain-containing protein -
LJD24_RS25105 (LJD24_25105) 74159..74284 - 126 Protein_63 IS481 family transposase -
LJD24_RS25110 (LJD24_25110) 74901..75149 + 249 WP_003527850.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
LJD24_RS25115 (LJD24_25115) 75139..75435 + 297 WP_017268214.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJD24_RS25120 (LJD24_25120) 75514..75774 - 261 Protein_66 helix-turn-helix domain-containing protein -
LJD24_RS25125 (LJD24_25125) 76348..76746 + 399 WP_010974988.1 hypothetical protein -
LJD24_RS25130 (LJD24_25130) 76913..77098 + 186 WP_015243548.1 hypothetical protein -
LJD24_RS25135 (LJD24_25135) 77102..77548 - 447 WP_014527651.1 DNA-binding protein -
LJD24_RS25140 (LJD24_25140) 77837..78046 + 210 WP_003527838.1 dodecin family protein -
LJD24_RS25145 (LJD24_25145) 78582..79961 + 1380 WP_027991363.1 sodium:alanine symporter family protein -
LJD24_RS25150 (LJD24_25150) 79998..80144 + 147 Protein_72 transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - htpB 1..1645902 1645902
- flank IS/Tn - - 74159..74350 191


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-93)

Antitoxin

(3-78)


Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 11490.20 Da        Isoelectric Point: 10.7543

>T220840 WP_017268214.1 NZ_CP085528:75139-75435 [Sinorhizobium meliloti]
MATERPFRLAPAAKADLRKIWRYKARRWSLEQAETYQDQLYTAFEGLAAGTKKGRNVDVRPGYLKYPAGSHIVYFRDRGD
RIDIIRILHGRMDAQRHL

Download         Length: 297 bp

>T220840 NZ_CP117298:c754814-754431 [Mycobacterium tuberculosis variant bovis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8888.73 Da        Isoelectric Point: 4.2176

>AT220840 WP_003527850.1 NZ_CP085528:74901-75149 [Sinorhizobium meliloti]
MAARSTSISLGDHFAGFIDSQVQTGRYGSASDVVRAGLRLLEEHEAKVRALEAALIEGEESGEPEPFDNEAFKAEMRAEY
GD

Download         Length: 249 bp

>AT220840 NZ_CP117298:c755064-754909 [Mycobacterium tuberculosis variant bovis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB H0FXK0

References